摘要
目的:讨论乙型肝炎患者慢性化与乙型肝病毒基因型的关系。方法:应用双探针荧光聚合酶链反应法,对杭州市的642例乙型肝炎病毒感染者进行乙肝病毒基因型检测,比较临床急性乙型肝炎和慢性乙型肝炎病毒基因型分布差异性。结果:642例乙肝病毒感染者中,基因B,C,BC混合型分别为31.93%,66.98%,1.09%。在慢性乙型肝炎组C型基因的比率远比急性乙型肝炎组要多(X2=13.19,P<0.05)。结论:杭州市乙型肝炎患者病毒基因型以C型为主,B型次之,少数为BC混合型。在不同基因型中,C型较B型更易转为慢性。
Objective： To explore the relationship between HBV genotype and chronic hepatitis B. Methods： Serum samples were collected from 642 HBV patients. HBV genotyping was performed with double probe polymerase chain reaction. Genotypes of acute hepatitis B and chronic hepatitis B virus were compared to analyze the distributional difference. Results： In 642 HBV infectors, the genotype B, C, BC combinations accounted for 31.93%, 66. 98%, 1.09% respectively. The ratio of genotype C in chronic hepatitis group was higher （X2 = 13.19, P 〈0.05 ）. Conclusion： In Hangzhou city, the HBV genotype C infection was dominant, followed by genotype B and mixed type of B and C. Compared with HBV genotype B, the genotype C HBV infection was more easily developed to chronic hepatitis B.
出处
《中国卫生检验杂志》
北大核心
2013年第6期1510-1510,1515,共2页
Chinese Journal of Health Laboratory Technology
