摘要
目的:探讨传染性单核细胞增多症患儿外周血淋巴细胞亚群的变化特点及其临床意义。方法:选取50例传染性细胞增多症患儿为IM组,30例健康体检儿童为对照组,采用流式细胞学方法检测两组患儿外周血的淋巴细胞亚群,作对比分析。结果:传染性单核细胞增多症患儿的CD8+T细胞和总T细胞明显升高(P<0.01),而CD4+T细胞、B细胞、NK细胞以及CD4/CD8比值显著降低(P<0.01)。结论:传染性单核细胞增多症患儿免疫系统表现为CD8+T细胞大量增殖,其它免疫细胞相对减少的免疫紊乱,对该病的发生发展具有重要意义。
Objective： To investigate the characteristic of the lymphocyte subsets and its clinical significance in children with infectious mononucleosis. Methods： Fifty children with infectious mononucleosis were selected as IM group, and 30 healthy children were selected as control group. Lymphocyte subsets of the two groups were detected by flow cytometry, and the differences between the two group were compared. Results： The total T cell and CD8＋ T cell of IM children were significantly higher （P 〈 0.01 ） than those of the controls, while the B cell, NK cell , CD4＋ T cell and CD4/ CD8 ratio were significantly lower（P 〈 0.01 ） than those of the controls. Conclusion： Massive proliferation of CD8 ＋ T ceils and decrease of other immune cells were detected in children with IM and it might be significant for the development of IM.
出处
《中国卫生检验杂志》
北大核心
2013年第6期1523-1524,共2页
Chinese Journal of Health Laboratory Technology
