利培酮对血清细胞因子的影响

Effect of Risperdal on serum cytokine

目的探讨利培酮对精神分裂症患者血清细胞因子的影响。方法对３９例精神分裂症患者给予利培酮治疗６周，在治疗前后检测血清ＩＬ－６， ＩＬ－８， ＩＦＮ－ｒ和ＴＮＦ－ａ水平，并采用ＰＡＮＳＳ量表和ＴＥＳＳ量表评估临床症状和药物副反应。结果利培酮治疗后，血清ＩＬ—６水平显著下降，治疗前血清ＩＬ—６水平与ＰＡＮＳＳ阳性因子分显著正相关，而血清ＩＬ—６减分率与药物最高剂量呈显著正相关，血清ＩＬ－８，ＩＦＮ－ｒ和ＴＮＦ－ａ水平变化不显著。结论精神分裂症精神症状可能与细胞因子的功能异常有关，利培酮可能因抑制ＩＬ－６的生成而起到免疫抑制作用。

Objective To study the effect of Risperdal on serum cytokines in schizophrenic patients. Method Serum IL - 6. IL - 8. IFN - r and TNF - a were measured in 39 schizophrenic patients before and after treatment with Risperdal for six weeks. Clinical features were measured with PANSS and side effect rated with TESS. Resutl The serum IL - 6 level was significantly decreased after Risperdal treatment, but there was no significant change in serum IL - 8. IFN -r and TNF - a leveal. Scores of positive factors of PANSS correlated positively with pretreatment serum IL - 6 level, but not IL - 8 .IFN - r and TNF - a level. The decrease in serum IL - 6 level after treatment correlated positively with maximum dosage of Risperdal reached. Conclusion The current study demonstrates that schizophrenic psychosis is associated with cytokine dysfunction