乙咪酯和异丙酚用于人工流产手术的比较

Comparison of etomidate and propofol in induced abortions

比较乙咪酯和异丙酚用于人工流产手术的麻醉效果及其对呼吸和循环功能的影响。方法 观察 46例行人工流产手术患者的麻醉效果 ,记录乙咪酯及异丙酚用量、手术时间、苏醒时间、SBP、DBP、HR、Sp O2 的变化以及不良反应发生率。结果 乙咪酯组给药后 Sp O2 明显低于给药前 ,异丙酚组给药后 SBP及 Sp O2 明显低于给药前 ,给药后异丙酚组 SBP及 Sp O2 明显低于乙咪酯组 ( P<0 .0 1) ,乙咪酯组术后恶心及术中肌震颤的发生率高于异丙酚组 ( P<0 .0 5 ) ,异丙酚组躁动的发生率明显高于乙咪酯组 ( P<0 .0 1)。结论 乙咪酯和异丙酚用于人工流产手术均可取得满意的麻醉效果 ,其对呼吸及循环功能的影响不需处理 ,两药均可较安全地用于人工流产手术。

Purpose To compare the anesthetic results and effects on respiratory and circulatlion functions of etomidate and propofol when they were used to induced abortions.Methods The anesthetic results of etomidate and propofol in 46 patients undergoing induced abortions were observed and the dose of etomidate and propofol,operation time,awaking time,changes of SBP、DBP、HR and SpO 2,and the incidence of various adverse effects were recorded.Results The postadministration SpO 2 of etomidate group was markedly lower than preadministration values (P<0.01).Compared to preadministration,the postadministration SBP and SpO 2 in propofol group was significantly lower (P<0.01).After administration,there were siginificantly lower SBP and SpO 2 in propofol group than in etomidate group (P<0.01).There were higher incidence of postoperation nausea and muscle thrill during the operation in etomidate group than in propofol group (P<0.05).The incidence of restless motion in propofol group was markedly higher than in etomidate group (P<0.01).Conclusions Etomidate and propofol have satisfactory anesthetic effects when they were applied to the induced abortions.The effects of propofol and etomidate on respiratory and circulation functions don't need to be treated.Both of them are safer in the induced abortions.