摘要
目的:通过硬膜外注射局麻药罗哌卡因,评价其对神经病理性疼痛模型大鼠的作用及其机制。方法:在坐骨神经损伤神经病理性疼痛大鼠模型(CCI)术后7 d,进行硬膜外置管手术,在术后8 d和11 d由硬膜外导管注入罗哌卡因,观测CCI大鼠机械痛阈(PWT)和脊髓后角纤维酸性蛋白(GFAP)的变化。结果:硬膜外注射罗哌卡因能够升高CCI大鼠患肢的机械痛阈,降低脊髓后角GFAP的表达。结论:在CCI大鼠模型硬膜外注射罗哌卡因可以较长时间抑制脊髓胶质细胞的激活,从而减轻神经病理性疼痛。
Objective： To evaluate the efficacy of epidural infusion of Ropivacaine for Neuropathic Pain model of rats and its mechanism.Methods： Perform epidural catheterization at Day 7 and inject Ropivacaine through epidural puncture tube at Day 8 and Day 11 after establishment of models of CCI rats,then investigate the changes of pain threshold and GFAP in the spinal dorsal horn of CCI rats.Results： Epidural infusion of ropivacaine could increase pain threshold of injured hind limb of CCI rats,attenuate expression of GFAP in the spinal dorsal horn.Conclusion： Epidural infusion of ropivacaine in the model of CCI rats could inhibit activation of spinal glial cells chronically and attenuate neuropathic pain.
出处
《现代生物医学进展》
CAS
2013年第17期3221-3224,共4页
Progress in Modern Biomedicine
基金
湖南省自然科学基金项目(10JJ3046)
