臂踝脉搏波速度与老年心血管病高危因素的相关性研究

Correlational Study Between Brachial-ankle Pulse wave Velocity and Risk Factors in Elderly Patients with Cardiovascular Disease

目的:探讨臂踝脉搏波速度(brachial-ankle pulse wave velocity,BaPWV)和心血管高危因素的相关性。方法:选取2011年1月～2012年1月在我院体检的居民共122例,根据体检结果分为非糖尿病及高血压组(A组,25例),糖尿病组(为B组,22例),高血压组(C组,46例)和高血压合并糖尿病组(D组,29例)。记录各组的年龄、体重指数(BMI)、收缩压(SBP),舒张压(DBP)、心率(HR)、左心房内径(LAD)、左室舒张末期内径(LVIDd)、左室收缩末期内径(LVIDs)、右心室舒张末期内径(IVSd)、肺动脉收缩压(SPAP)和射血分数(EF)。并检测肌酐(Scr)、尿酸(UA)、血糖(BG)、总胆固醇(TC)、甘油三酷(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、餐后血糖和糖化血红蛋白(HbA1c)水平。结果:各组之间Scr、UA、BG、TC、LDL、HbA1c、LAD、LVIDd、IVSd、LVIDs、SPAP、IMT、SBP、DBP、EF和BaPWV的差异有统计学意义(P<0.05或<0.01),而各组之间年龄、BMI、TG、HDL、餐后血糖、IMT和HR差异无统计学意义(P>0.05)。多元逐步回归分析发现:年龄、BG、TC和SBP是影响BaPWV的独立因素。结论:BaPWV在心血管高危因素患者中显著增加,年龄、BG、TC和SBP与BaPWV呈正相关。

Objective：To investigate the correlation between brachial-ankle pulse wave velocity（BaPWV） and risk factors in elderly patients with cardiovascular disease.Methods：122 cases for examination in our hospital from January 2011 to January 2012 were divided into three groups：no diabetes and hypertension group（group A,n =25）,diabetic group（group B,22 cases）,hypertension group（group C,n=46）,and hypertension and diabetic group（group D,n = 29）,according to the examination results.The age,body mass index（BMI）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,heart rate（HR）,left atrial dimension（LAD）,left ventricular end-diastolic diameter（LVIDd）,left ventricular systolic diameter（LVIDs）,right ventricular end-diastolic diameter（IVSd）,systolic pulmonary artery pressure（SPAP） and ejection fraction（EF） were recorded.The levels of creatinine（Scr）,uric acid（UA）,blood glucose（BG）,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL）,low density lipoprotein cholesterol（LDL）,postprandial blood glucose and glycosylated hemoglobin（HbA1c） were also detected.Results：There were statistically significant differences in Scr,uric acid,BG,TC,LDL,HbA1c,LAD,LVIDd,IVSd,LVIDs,SPAP,IMT,SBP,DBP,EF and BaPWV among each group（P0.05 or 0.01）,but there were no differences in age,BMI,TG,HDL,postprandial blood glucose,IMT and HR（P 0.05）.The age,BG,TC,and SBP were independent factors affecting BaPWV from stepwise multiple regression analysis.Conclusion：BaPWV increases in patients with cardiovascular high-risk factors,and is positively correlated with age,BG,TC,and SBP.