颞下颌关节创伤性骨关节炎及其发病机制研究进展

Research progress of temporomandibular joint post-traumatic osteoarthritis and its pathogenesis

颞下颌关节(temporomandibular joint,TMJ)创伤性骨关节炎(post-traumatic osteoarthritis,PTOA)是由于创伤导致的关节软骨退行性变,临床表现为持续性关节疼痛并可放射到颈肩部肌肉、关节弹响或摩擦音、张口受限、咀嚼无力等。病理表现为关节软骨丧失、骨赘形成和软骨下骨硬化。目前的治疗主要是药物缓解症状和晚期病变的人工关节置换,尚缺乏在病变早期有效中止甚至逆转病变进展的药物治疗,为此有必要理解其发病机制,寻找有效的药物靶点。本文就近年来TMJPTOA及其发病机制的研究进展做一综述。

Temporomandibular joint （TMJ） post-traumatic osteoarthritis （PTOA） is defined as progressive articular car- tilage degeneration caused by trauma. Clinical manifestations are persistent pain which could radiate to neck and shoul- der muscles, joint clicking or crepitus, limitation of mouth opening and weakness of chewing. Pathology shows loss of ar- ticular cartilage, osteophyte formation and subchondral bone sclerosis. The current treatment is mainly drugs administra- tion to relieve pain and artificial joint replacement for advanced lesions. There is still a lack of effective medication to stop or even reverse the progression in the early stage of PTOA. In order to look for effective targets it is necessary to un- derstand the pathogenesis. TMJ PTOA and its pathogenesis research progress were reviewed in this article.