摘要
颞下颌关节(temporomandibular joint,TMJ)创伤性骨关节炎(post-traumatic osteoarthritis,PTOA)是由于创伤导致的关节软骨退行性变,临床表现为持续性关节疼痛并可放射到颈肩部肌肉、关节弹响或摩擦音、张口受限、咀嚼无力等。病理表现为关节软骨丧失、骨赘形成和软骨下骨硬化。目前的治疗主要是药物缓解症状和晚期病变的人工关节置换,尚缺乏在病变早期有效中止甚至逆转病变进展的药物治疗,为此有必要理解其发病机制,寻找有效的药物靶点。本文就近年来TMJPTOA及其发病机制的研究进展做一综述。
Temporomandibular joint (TMJ) post-traumatic osteoarthritis (PTOA) is defined as progressive articular car- tilage degeneration caused by trauma. Clinical manifestations are persistent pain which could radiate to neck and shoul- der muscles, joint clicking or crepitus, limitation of mouth opening and weakness of chewing. Pathology shows loss of ar- ticular cartilage, osteophyte formation and subchondral bone sclerosis. The current treatment is mainly drugs administra- tion to relieve pain and artificial joint replacement for advanced lesions. There is still a lack of effective medication to stop or even reverse the progression in the early stage of PTOA. In order to look for effective targets it is necessary to un- derstand the pathogenesis. TMJ PTOA and its pathogenesis research progress were reviewed in this article.
出处
《中国实用口腔科杂志》
CAS
2013年第6期370-374,共5页
Chinese Journal of Practical Stomatology
基金
上海市科学技术委员会资助项目(08DZ2271100)
卫生行业公益基金(201002017)
关键词
颞下颌关节
创伤性骨关节炎
发病机制
temporomandibuIar joint
post-traumatic osteoarthritis
pathogenesis