心理干预对先兆流产患者免疫机制影响的初步研究

A preliminary study on effect of psychological intervention on immune mechanism of threatened abortion

目的:探讨心理干预在先兆流产治疗中的临床疗效及其对免疫机制的影响。方法:以先兆流产孕妇施行常规治疗+心理干预80例作为研究组,以先兆流产孕妇施行常规治疗80例作为对照组A,以同期无流产病史的早孕妇女80例作为对照组B。以SCL-90症状自评量表评估心理干预对先兆流产孕妇心理状况及疗效的影响,测定各组考的松(Cortisol)、IL-2、IL-10及TGF-β1水平,分析其对先兆流产患者内分泌的影响。结果:先兆流产组与无流产病史组相比,SCL-90评分、Cortisol及IL-2水平显著增高,IL-10和TGF-β1水平显著降低;心理干预组与常规治疗组相比,SCL-90评分、Cortisol及IL-2水平显著降低,IL-10和TGF-β1水平及妊娠成功率显著增高。结论:心理干预可能通过影响先兆流产患者免疫机制发挥治疗作用。

Objective： To explore the clinical curative effect of psychological intervention in treatment of threatened abortion and the impact on immune mechanism.Methods： Eighty patients with threatened abortion who were treated with routine therapy and psychological intervention were selected as study group,eighty patients with threatened abortion who were treated with routine therapy were selected as control A group,and eighty normal pregnant women without abortion history during the same period were selected as control B group.SCL 90 was used to evaluate the effect of psychological intervention on psychological status and curative effect of patients with threatened abortion,the levels of Cortisol,IL-2,IL-10 and TGF-β1 in the three groups were detected,the effect on endocrine of patients was analyzed.Results： Compared with non-abortion group,SCL-90 score,Cortisol and IL-2 levels in threatened abortion group increased significantly,while the levels of IL-10 and TGF-β1 decreased significantly;compared with routine therapy group,SCL-90 score,Cortisol and IL-2 levels in psychological intervention group decreased significantly,the levels of IL-10 and TGF-β1 and successful rate of pregnancy increased significantly.Conclusion： Psychological intervention may play a curative role by affecting the immune mechanism of threatened abortion.