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HLA-G表达差异与原因不明习惯性流产的关系 被引量：6

Relationship between differential expression of HLA-G and unexplained recurrent spontaneous abortion
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摘要 目的:探讨人类白细胞抗原G(HLA-G)蛋白在正常妊娠和原因不明习惯性流产绒毛滋养细胞中的表达及其与两者的关系。方法:采用免疫组化法检测HLA-G蛋白在原因不明习惯性流产组(n=19)和正常妊娠组(对照组)(n=29)的表达情况。结果:HLA-G在原因不明习惯性流产组的表达明显低于对照组,差异有统计学意义(P<0.01)。结论:HLA-G蛋白的表达下调可能是原因不明习惯性流产发生的因素。 Objective： To explore the expressions of human leukocyte antigen-G（HLA-G） protein in trophoblasts of normal pregnancy and unexplained recurrent spontaneous abortion（URSA） and its relationship with normal pregnancy and URSA.Methods： Immunohistochemical method was used to detect the expressions of HLA-G protein in URSA group（n = 19） and normal pregnancy group（control group）（n =29）.Results： The expression level of HLA-G protein in URSA group was statistically significantly lower than that in control group（P 0.01）.Conclusion： Down-regulation of HLA-G protein may be one of causes of URSA.
作者 康小玲 郜红艺 吴坤河 李辉斌 廖燕霞 凌月仙
机构地区 广东省妇幼保健院病理科
出处 《中国妇幼保健》 CAS 北大核心 2013年第19期3142-3143,共2页 Maternal and Child Health Care of China
基金 广东省医学科研基金〔A2009074〕
关键词 人类白细胞抗原G(HLA-G) 原因不明习惯性流产 绒毛 Human leukocyte antigen-G Unexplained recurrent spontaneous abortion Villi
分类号 R737.9 [医药卫生—肿瘤]
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参考文献10

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二级参考文献8

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共引文献77

同被引文献50

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引证文献6

二级引证文献24

中国妇幼保健
2013年 第19期

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