鳞状细胞癌相关抗原检测在宫颈癌诊断中的应用分析

Analysis of squamous cell carcinoma antigen detection in diagnosis of cervical carcinoma

目的探讨鳞状细胞癌相关抗原(SCC)检测在宫颈癌诊断中的应用价值。方法收集我院2010年1月到2011年1月收治的88例宫颈癌患者(观察组)和同期68例健康女性(对照组)血清样本,用ARCHITECT sr2000全自动免疫分析仪测定SCC水平值。结果观察组血清SCC阳性率明显高于对照组,差异有统计学意义(P<0.05);宫颈癌Ⅳ期SCC浓度值和阳性率明显高于宫颈癌Ⅰ-Ⅲ期期情况,差异有统计学意义(P<0.05);宫颈癌治疗后SCC浓度值明显低于治疗前SCC值,差异有统计学意义(P<0.05)。结论 SCC是诊断宫颈癌特异性较强的标志物,值得临床诊断中推广应用。

Objective To investigate the level of squamous cell carcinoma antigen （SCC） and the significance of SCC detection in the diagnosis of cervical cancer. Methods Admitted to our hospital from January 2010 to January 2011,88 cases of cervical cancer patients （observation group） and 68 healthy women of the same period （control group） were recruited in the study of the plasma samples. Automated immunoassay analyzer ARCHITECT si2000 was used to determine SCC level, SCC positive rate was observed in patients with different stages of SCC concentration values, and comparative analysis of cervical cancer SCC changes was made before and after treatment. Results The observed plasma SCC positive rate was significantly higher than that in the control group, and the difference was statistically significant （ P 〈 0.05 ） ; SCC concentration and positive rate in cervical carcinoma stage IVwas significantly higher than that in cervical cancer I - I8 peri- od, and the difference was statistically significant（ P 〈 0.05 ） ; SCC concentration of cervical cancer after the treatment was significantly lower than that of pre - treatment, and the difference was statistically significant （P 〈 0.05）. Conclusion SCC is one of the specificity markers of cervical cancer, and the detection of SCC is a new method for the diagnosis of cervical cancer, which is worth promotion and application in clinical diagnosis.