含奥沙利铂的化疗及介入化疗方案治疗晚期原发性肝癌的临床研究

Clinical research of chemotherapy and interventional chemotherapy regimens containing oxaliplatin in the treatment of advanced primary liver cancer

目的探讨含奥沙利铂的化疗及介入化疗方案治疗晚期原发性肝癌的临床效果。方法将我院收治的90例晚期原发性肝癌患者随机分为对照组和观察组各45例,对照组给予奥沙利铂、亚叶酸钙和氟尿嘧啶的化疗方案单纯全身化疗,观察组采用改良Seldinger方法给予介入化疗。比较两组患者的近期疗效、远期疗效、治疗前后的生活质量改善情况以及不良反应发生情况等。结果观察组临床有效率(73.3%)及临床获益率(93.3%)显著高于对照组,差异有统计学意义(P<0.05);观察组中位生存期(19.8±5.3)个月,总生存期(40.6±12.5)个月显著长于对照组,差异有统计学意义(P<0.05);观察组与对照组治疗前生存质量评分差异无统计学意义(P>0.05)。观察组治疗后生存质量评分显著高于对照组,差异有统计学意义(P<0.05)。观察组Ⅲ、Ⅳ度血液及胃肠道不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论含奥沙利铂的介入化疗疗效佳,不良反应少,患者生存质量高,值得临床推广应用。

Objective To study the clinical effect of chemotherapy and interventional chemotherapy regi- mens containing oxaliplatin in the treatment of advanced primary liver cancer. Methods Ninety patients with ad- vanced primary liver cancer were randomly divided into the control group and the observation group, with 45 cases in each group. The control group was given systemic chemotherapy alone, while the observation group was given inter- ventional chemotherapy. The short-term curative effect, long-term curative effect, patients＇ quality of life before and af- ter treatment, adverse reactions were compared between the two groups. Results The clinical effective rate （73.3%） and clinical improvement rate （93.3%） of the observation group were significantly higher than those of the control group, and the difference was statistically significant （P〈0.05）. The median survival （19.8±5.3） months and overall survival （40.6± 12.5） months of the observation group were significantly longer than those of the control group, and the difference was statistically significant （P〈0.05）. The score in quality of life showed no statistically significant dif- ference between the two groups before treatment （P〉0.05）, but the score was significantly higher in the observation group after treatment （P〈0.05）. The incidences of III, IV blood and gastrointestinal adverse reactions in the observa- tion group were significantly lower than those of the control group （P〈0.05）. Conclusion The curative effect ofinter- ventional chemotherapy containing oxaliplatin is good, with less adverse reactions, higher quality of life, which is wor- thy of clinical popularization and application.