CTLA-4基因rs231775位点多态性与原发性高血压易感性的关系

ASSOCIATION OF CTLA-4 GENE rs231775 POLYMORPHISM WITH ESSENTIAL HYPERTENSION SUSCEPTIBILITY

目的:探讨细胞毒性T淋巴细胞相关抗原4(CTLA-4)基因rs231775位点多态性与原发性高血压(essential hyperten-sion,EH)易感性的关系。方法:采用病例—对照研究方法,运用基质辅助激光解析电离飞行时间质谱技术(MALDI-TOF-MS)对406例EH患者(病例组)和723例健康对照者(对照组)的CTLA-4基因rs231775位点进行多态性检测,分析基因型频率及等位基因频率在病例组和对照组中的分布,研究其基因型和等位基因与EH易感性的关系。结果:CTLA-4基因rs231775位点的基因型频率及等位基因频率在病例组和对照组中的分布差异无统计学意义(P>0.05);与AA基因型相比,AG或者GG基因型与EH患病风险无统计学关联(校正OR=0.751,95%CI 0.498～1.134,P=0.174;校正OR=0.772,95%CI 0.505～1.179,P=0.230),携带等位基因G亦与EH患病风险无关联(校正OR=0.760,95%CI 0.515～1.122,P=0.168)。结论:CTLA-4基因rs231775位点多态性与原发性高血压易感性可能无关。

Objective： To investigate the relationship between cytotoxic T lymphocyte-associated antigen 4 （CTLA-4） gene rs231775 polymorphism and essential hypertension （EH） susceptibility. Methods： A case- control study was performed. A total of 406 EH patients （cases） and 723 normal controls （controls） were detected the CTLA-4 rs231775 polymorphism by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry technology, and the distribution of genotypic and allelic frequencies was analyzed in the cases and controls, and the relations of genotype and allele with EH susceptibility were studied. Results： There was no significant difference on the distribution of genotypic and allelic frequencies between cases and controls; compared with the AA genotype, it was not statistically association between AG or GG genotype and the risk of EH; and carrying allele G was not related with the risk of EH. Conclusion： There was noassociation between CTLA-4 gene rs231775 polymor- phism and EH susceptibility.