黑黄胶囊治疗美菲康所致便秘的临床观察

Clinical observation of Heihuang capsule in treating constipation caused by morphine hydrochloride

[目的]探讨黑黄胶囊治疗美菲康所致便秘的临床价值。[方法]72例服用美菲康出现便秘的肿瘤患者随机分为治疗组(36例)和对照组(36例)。治疗组服用黑黄胶囊(药物组成:黑豆、马齿苋、生大黄、肉苁蓉、干芹菜),由天津北辰医院制剂室制成胶囊,每粒含生药0.5 g,每次6粒,每次饭前15 min温开水送服,每日2次。治疗期间停用其他各种通便药。对照组服用麻仁丸9 g,每日早晚口服。14 d为1个疗程,连续服药1个疗程后观察疗效。[结果]在便秘治疗的有效率及便秘伴随临床症状改善情况两方面比较,治疗组明显优于对照组,两组间差异有统计学意义(P<0.05)。[结论]黑黄胶囊能够有效治疗美菲康所致便秘,值得临床推广。

The 72 patients with tumor having constipation caused by taking morphine hydrochloride were randomly divided into therapy group （36 cases） and control group （36 cases）. Patients in therapy group took Heihuang capsules （drug ingredient： black beans, purslane, raw rhubarb, desertliving cistanche, celery）. The capsules were made by the preparation lab of our hospital, and each capsule contained 0.5 g of crude drugs. The 6 capsules were given twice a day, 15 minutes before meals with warm water. During treatment any other cathartic was stopped. Patients in the control group took Maren pills, 9 g twice a day in the morning and in the evening. Fourteen days were a course of treatment. We observed the curative effect after continuous medication for one course of treatment. [Results] The treatment group was better than control group in the effective rate and associated symptoms improvement of constipation. There was a significant difference between both groups （P〈0.05）. [Conclusion] Heihuang capsule can effectively treat the constipation caused by morphine hydrochlride and it is worth popularizing.