盐酸戊乙奎醚对异位妊娠失血性休克手术患者微循环的影响

Effect of penehyclidine hydrochloride on microcirculation in patients with ectopic pregnancy in operation for hemorrhagic shock

[目的]观察盐酸戊乙奎醚对失血性休克手术患者微循环的影响。[方法]选择妇科异位妊娠失血性休克需急诊手术的患者90例,将患者按随机数字表示法分为治疗组盐酸戊乙奎醚组(A组,45例)和对照组生理盐水(B组,45例),A组患者麻醉诱导前静脉注射盐酸戊乙奎醚0.06 mg/kg;B组患者麻醉诱导前静注0.9%生理盐水2 mL,余处理同A组。观察两组患者的心排指数(CI)、指端的血氧饱和度(SPO2)及动脉血氧含量(CaO2),麻醉诱导1 h后测量静脉血乳酸(VBL)含量,并记录此时的心率(HR)、平均动脉压(MAP)以及围手术中尿量。[结果]A组VBL(静脉血乳酸)含量较B组显著降低(P<0.05);A组(血氧饱和度)SPO2较B组显著提高(P<0.05);A组C(I心排指数)较B组显著增加;A组术中尿量较B组明显增多(P<0.05)。[结论]盐酸乙奎醚能明显改善失血性休克患者微循环的功能。

[Objective] To observe the effect of penehyelidine hydrochloride on microcirculation of patients in operation for hemorrhagic shock. [Methods] Ninety patients with ectopic pregnancy in hemorrhagic shock, who needed emergency operation, were randomly divid- ed into penehyclidine hydrochloride group （group A, 45 eases） and control group （group B, 45 cases）. Patients in group A were infused in- travenously penehyclidine hydrochloride, 0.06 mg/kg, before induction of anesthesia; while patients in group B were received 2 mL 0.9% saline. Finger tip blood oxygen saturation （SPO2）, arterial oxygen content（CaO2） and Cardiac index（CI） were observed in all the patients. 1 h after anesthesia induction the content of venous blood lactic acid （VBL） was measured, the heart rate （HR）, mean arterial pressure （MAP） and urine volume in perioperative period were also recorded. [Results] Compared with group B, the content of VBL in group A was signif- icantly decreased （P〈0.05）; SPO2 in group A was higher significantly than that in B group （P〈0.05）; CI in group A was increased signifi cantly than group B ;urine output in group A was significantly increased than that in group B （P〈0.05）. [Conclusion] Penehyclidine hy- drochloride can improve the microcireulation function in patients with hemorrhagic shock.