过敏性紫癜食物特异性IgG检测及禁食/轮替治疗疗效观察

Detection of food specific IgG and observation of the therapeutic effect of fast/alternate treatment in patients with henoch-schomlein purpura

目的检测单纯型过敏性紫癜患者血清14种食物特异性免疫球蛋白G(IgG),并应用禁食/轮替治疗观察复发率。方法采用酶联免疫吸附法(ELISA)检测62例单纯型过敏性紫癜及60例健康对照组血清14种食物特异性IgG抗体水平,将62例单纯型过敏性紫癜分为治疗组32例及对照组30例,治疗组行禁食/轮替治疗,对照组行未控制饮食的常规治疗,6个月后观察复发率并检测二组IgG水平。结果单纯型过敏性紫癜患者IgG水平高于健康对照组,两组差异有统计学意义(P<0.05);单纯型过敏性紫癜患者治疗6个月后IgG均下降,且治疗组较对照组下降明显,差异有统计学意义(P<0.05);于6个月后对两组做问卷调查,治疗组复发率6.67%。对照组复发率33.33%;两组比较,差异有统计学意义(P<0.05)。结论食物特异性IgG抗体水平与单纯型过敏性紫癜有相关性,禁食/轮替治疗对本病的防治有重要意义。

Objective To detect 14 kind of food specific IgG in patients with simple type henoch-schonlein purpura,and observe the recurrence rate after fast/alternate treatment.Methods 14 kind of food specific IgG levels in 62 cases of simple type henoch-schonlein purpura and 60 healthy people were tested by ELISA.The 62 simple type HSP patients were divided into the treatment group（32 cases） and control group（30 cases）.Treatment group underwent fast/alternate treatment,and the control group underwent conventional therapy,IgG level and the recurrence rate 6 months after treatment in groups were analyzed.Results IgG levels of in patients with simple type henoch-schonlein purpura was higher than that of healthy group,with significant difference（P0.05）.The level of IgG in patients with simple type henoch-schonlein purpura decreased 6 months after treatment,and the level of IgG in treatment group was lower than that of control group,with significant difference（P0.05）.The two groups have questionnaire after six months.Recurrence rate of the treatment group was 6.67% and that of control group was 33.33%,which showed significant difference（P0.05）.Conclusion The food specific IgG level has correlation with simple type henoch-schonlein purpura.Fast/alternate treatment is of good value for this disease.