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贝前列腺素钠治疗高龄老年不稳定性心绞痛的临床观察 被引量:6

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摘要 目的观察贝前列腺素钠治疗老年不稳定性心绞痛(UAP)的临床疗效。方法选择UAP老年患者98例,随机分为对照组47例,给予常规治疗,治疗组51例,在常规治疗基础上加用贝前列腺素钠。结果与对照组相比,治疗组心绞痛症状改善总有效率明显增加(P<0.05),24h缺血发作次数、总缺血时间、最长持续时间、室性早搏次数均显著减少(P<0.01),纤维蛋白原水平,小板聚集率均较治疗前显著降低(P<0.01),收缩压、舒张压均较治疗前下降(P<0.05),与对照组比较,治疗组未增加不良反应的发生。结论在常规治疗基础上加用贝前列腺素钠治疗老年UAP安全有效。
出处 《重庆医学》 CAS CSCD 北大核心 2013年第19期2258-2260,共3页 Chongqing medicine
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  • 1魏仲航,孙晓莉,石伟东.老年不稳定性心绞痛临床特点[J].中国实验诊断学,2004,8(4):363-364. 被引量:8
  • 2张艳,金津,李乐雯.老年不稳定性心绞痛98例临床分析[J].2009,15(8):892-893.
  • 3Braunwald Ev Antman EM, BeasleyJW. ACC/ AHA guideline update for the management of patients with unstable angi?na and non-ST-segment elevation myocardial infarction-- 2002: summary article: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines(Committee on the Management of Pa?tients With Unstable Angina)[J]. 2002,106 (14) : 1893- 1900.
  • 4Vargas-Alarcon G, Fragoso] M, Delgadillo H. Acute coro?nary syndrome[J]. Physiopathology and Genetics Rev In?vest Clin, 2011, 63 (1) : 64-74.
  • 5ArmstrongJ ,Lattimer N, Moncada S, et al .Cornparison of the vaso-depressor effects ofprostacyclin and 6-oxo-pros?taglandin Flalpha with those of prostaglandin E2 in rats and rabbits[J]. BrJ Pharmacol,1978,62,125-130.
  • 6Sugawara A,Kudo M,Saito A. Novel effects of beraprost sodium on vasculatures[J]. Int Angiol , 2010, 29 (2 Sup?pl) : 28-32.
  • 7Kainoh M,Maruyama I, Nishio Sv ct al. Enhancement by beraprost sodium, a stable analogue of prostacyclin , in thrombomodulin expression on membrane surface of cul?tured vascular endothelial cells viaincrease in cyclic AMP level. Biochem[J]. Pharmacol , 1991,41: 1135-1140.
  • 8Miyamoto M,Ohno M, Yamada N. TRA-418 , a throm?boxane A2 receptor antagonist and prostacyclin receptor agonist, inhibits platelet-leukocyte interaction in human whole blood[J]. Thromb Haemost, 2010, 104 (4) : 788- 795.
  • 9Moriya H,Ishioka K,Honda K,et al. Beraprost sodium, an orally active prostagland l( 2) analog, improves renal a?nemia in hemodialysis patients with peripheral arterial disease[J]. Ther Apher Dial,2010,14(5) :472-476.
  • 10Gomberg-Maitland M, Olschewski H. Prostacyclin thera?pies for the treatment of pulmonary arterial hypertension[J]. Eur RespirJ ,2008,31(4) :891-901.

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  • 1刘武,吴修信.前列地尔治疗脑出血后肺血栓栓塞症的研究[J].现代中西医结合杂志,2005,14(14):1823-1824. 被引量:3
  • 2柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304. 被引量:2108
  • 3Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association [ J ]. Circulation, 2011,123(16) :1788 -1830.
  • 4Stein Paul D, Matta Fadi, Sabra MJ. Case fatality rate with vena cava filtem in hospitalized stable patients with cancer and pulmonary em- bolism[ J]. Am J Med,2013,126(9) :819 -824.
  • 5Kristiansen A, Brandt L, Agoritsas T, et al. Applying new strategies for the national adaptation, updating, and dissemination of trustwor- thy guidelines: results from the Norwegian adaptation of the An- tithrombotic Therapy and the Prevention of Thrombosis,9th Ed:A- merican College of Chest Physicians Evidence - Based Clinical Prac- tice Guidelines [ J]. Chest ,2014,146 ( 3 ) :735 - 761.
  • 6Day RW. Differences in the Acute Pulmonary Vascular Effects of Ox- ygen with Nitric Oxide and Dihiazem :Implications for the Long-term Treatment of Puhnonary Arterial Hypertension [ J ]. Congenit Heart Dis,2012,8 ( 1 ) :13 - 19.
  • 7Wang L, Wu J, Zhang W, et al. Effects of aspirin on the ERK and PDK/Akt signaling pathways in rats with acute pulmonary embolism [J]. Mol Med Rcp,2013,8(5) :1465 - 1471.
  • 8Nagaya N. Oral beraprost sodium improves exercise capacity and ventilatory efficiency in patients with primary or thromboembolic pul- monary hepertension [ J ]. Heart,2002,87 ( 4 ) : 340 - 345.
  • 9JneidH,AndersonJL,WrightRS,etal.2012ACCF/AHAfo-cusedupdateoftheguidelineforthe managementofpatientswith unstable angina/non-ST-elevation myocardialinfarction(updatingthe2007guidelineandreplacingthe2011focusedup-date):areportoftheAmericanCollegeofCardiologyFounda-tion/American Heart Association Task Force on PracticeGuidelines[J].JAm CollCardiol,2012,60(7):645-681.
  • 10RiezebosRK,RonnerE,TerBalsE,etal.Immediateversusde-ferredcoronaryangioplastyinnon-ST-segmentelevationacutecoronarysyndromes[J].Heart,2009,95(10):807-812.

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