1Platanias LC. Abnormalities in Th17 T cells in aplastic a nemia[J]. Blood, 2010,116(20) : 40394040.
2Solomou EE,Rezvani K,Mielke Sv et al. Deficient CD4+ CD25+ FOXP3T T regulatory cells in acquired aplastic a nemia[J]. Blood, 2007, 110( 5) : 1603 1606.
3Bettelli E, Carrier Y, Gao W, et al. Reciprocal develop?mental pathways for the generation of pathogenic effector Th17 and regulatory T cell[J]. Nature, 2006,441: 235 23S.
4Awasthi A, Murugaiyan G, Kuchroo VK, et al. Interplay between effector Th17 and regulatory T cells[J]. Clin Im?munol,200S,2S(6) :660667.
5Gu Y,Hu X,Liu c,? al. Inter leukin I Il.Yr l ? promotes macro phages to produce ILS, IL6 and tumour necrosis factor-alpha in aplastic anaemia[J]. BrJ Haematol, 200S, 142(1) :109114.
6Peffault de Latour R, Visconte V. Th17 immune respon?ses contribute to the pathophysiology of aplastic anemia[J]. Blood,2010,116(20) :417541S4.
7Mosmann TR, Cherwinski H, Bond MW ,et al. Two types of murine helper T cell clone I Definition according to profiles of lymphokine activities and secreted proteins[J]. Immunol , 19S6, 136: 234S2357.
8Harrington LE, Mangan PR, Weaver CT, et al: Expan?ding the effector CD4 Tv cell repertoire: the Th17 lineage[J]. Curr Opin Immunol, 2006, lS(3) : 349356.
9Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, Tbet, directs Th1 lineage commitment[J]. Cell, 2000,100:655659.
10FontenotJD, Rudensky A Y. A well adapted regulatory contrivance: regulatory T cell Development and the fork?headfamily transcription factor Foxp3[J]. Nat immunol , 2005,6(4):331337.
2Veldhoen M,Hocking RJ,Atkins CJ,et al.TGF-β in the context of an inflammatory cytokine milieu supports denovo differentiation of IL-17-producing T cells.Immunity,2006,24:179-189.
3Kuwana M,Kawakami Y,Ikeda Y.Suppr ession of autoreactive T2 cell response to glycoprotein Ⅱ b/Ⅲ a by blockade of CD40/CD154 interaction:implications for treatment of immune thrombocytopenic purpura.Blood,2003,101:621-623.
4Ivanov Ⅱ,Mekenzie BS,Zhou L,et al.The orphan nuclear receptor ROR-γt directs the differentiation program of proinflammatory IL17^+T helper cells.Cell,2006,126:1121 -1133.
5Sakakura M,Wada H,Tawara I,et al.Reduced CD4^+ CD25^+T cells in patients with idiopathic thrombocytopenic purpura.Thromb Res,2007,120:187-190.
6Ma DX,Zhu XJ,Zhao P,et al.Profile of Th17 cytokines (IL-17,TGF-β,IL-6) and Th1 cytokine (IFN-r) in patients with immune thrombocytopenic purpura.Ann Hematol,2008,87:899-901.
7Zhou RF,Yang JQ,Chang DY,et al.Profiles of Th1,Th2,Th17 and Treg Cells in Patients with Chronic Idiopathic Thrombocytopenic Purpura.Blood (ASH Annual Meeting Abstracts),2008,112:4907.
9Li F,Zou SH,Cheng YF,et al.Elevated expression of IL-17 and IL-23 in patients with immune thrombocytopenic purpura.Blood (ASH Annual Meeting Abstracts),2008,112:3428.
10Zhang J,Ma D,Zhu X,et al.Elevated profile of Th17,Th1and Tc1 cells in patients with immune thrombocytopemc purpura.Haematologica,2009,94:1326-1329.
