血清唾液酸和超敏C反应蛋白与高血压前期的相关性研究

Association between sialic acid and high sensitivity C-reactive protein in prehypertension patients

目的探讨血清唾液酸（sA）、超敏c反应蛋白（hs-CRP）与高血压前期的关系及临床意义。方法本研究属于临床病例对照研究。收集中日友好医院2011年的181名体检者标本，测量血压、身高、体重，调查生活习惯、疾病史等情况，按照血压水平分为血压正常组（n=50）、高血压前期组（n=61）、高血压组（／Z=70）检测血糖、血脂、血清SA、血压、hs-CRP、体质量指数（BMI），采用多元线性逐步回归分析血清SA、hs-CRP对血压的影响。结果三组间收缩压（SBP）、舒张压（DBP）、SA、hs-CRP、BMI和高密度脂蛋白（HDL）水平比较，差异均有统计学意义（P〈0．05）。低密度脂蛋白（LDL）、总胆固醇（TC）、空腹血糖（FBG）在高血压组和对照组间有显著性差异（P〈0．05）。多元线性回归分析显示，FBG、BMI、SA、hs-CRP与SBP独立相关（P〈0．05），LDL、BMI、SA、hs-CRP与DBP独立相关（P〈0．05）。结论血清SA和hs-CRP与血压独立相关，可以作为高血压前期的检查指标。

Objective To evaluate the serum concentration of sialic acid （SA） and High sensitivity C-reactive protein （hs-CRP） in prehypertension patients and possible correlation of the two factors and blood pressure in prehypertension patients. Methods 61 prehypertension patients, 70 hypertension patients and 50 healthy controls were included. Lipid profile, hs-CRP, SA, and body mass index （BMI） were estimated in all the groups. Associations between SA and hs-CRP and blood pressure were analyzed by multiple linear regressions. Results The levels of SA and hs-CRP were higher in the prehypertension group than those in the normal group and lower than those in the hypertension group （P 〈 0. 05 ）. There was significant difference in systolic blood pressure （ SBP）, diastolic pressure （DBP） , BMI and HDL among the three groups （ P 〈 0.05）. There was significant difference between the prehypertension group and the hypertension group in LDL,TC and FBG. Multiple linear regression showed that FBG, BMI, SA and hs-CRP were correlated with SBP independently while LDL, BMI, SA and hs-CRP were correlated with DBP independently （P 〈 0.05）. Conclusions The findings of the present study suggest that, there is an association between blood pressure and the levels of serum SA and hs-CRP which might be used as screening biomarkers in prehypertension.