受体相互作用蛋白1RIP1在食管鳞癌的表达及意义

Expression and significance of receptor interacting protein 1 in esophageal squamous cell cancer

目的明确受体相互作用蛋白1 RIP1在人食管鳞癌组织中的表达及与临床病理因素、病人预后的关系。方法使用免疫组化SP法检测76例人食管鳞癌组织和相对应的癌旁正常食管黏膜中RIP1的表达状况,并分析与临床病理因素如病人的性别、年龄、肿瘤大小、浸润深度、临床分期、分级、有无淋巴结转移的关系,并进行了随访。结果76例食管鳞癌中RIP1阳性的病例有53例,占69.7%,癌旁组织RIP1阳性的只有19例,占25%,差异有统计学意义,RIP1的阳性表达与病人的性别、年龄、肿瘤大小无关,与浸润深度、临床分期、分级、有无淋巴结转移成正相关,随访结果表明:食管鳞癌中RIP1阳性率越高,病人生存期越短,预后越差,RIP1蛋白的表达是个预后不良的独立因素。结论 RIP1在食管鳞癌中表达增高,可能参与食管鳞癌的发生。

Objective To investigate the expression of receptor interacting protein 1（RIP1） in esophageal squamous cell cancer（ESCC） and its link with clinical pathologic data and prognosis.Methods Imunohistochemistry was applied to analysize the expression status of RIP1 in seventy-six esophageal squamous cell cancer tissues and corresponding adjacent paracancerous normal tissues.Then Kaplan-Meier survival analysis and Cox proportional hazard regression model was used to test the association between expression status of RIP1 and clinical pathologic data,total survival rate induced from follow-up.Results Among 76 cases,positive expression of RIP1 in ESCC tissues was found in 53 cases and it accounts for 69.7%.Positive rate in corresponding adjacent normal tissues was 25%.The difference was significant.Moreover,positive rate of RIP1 in cancerous tissues was positive related to invasion depth,clinical stage,pathologic grade,lymph node metastasis,but it was not associated with patient’s sex,age,tumor mass.Follow-up suggested positive rate was more higher,patient’survival time was more shorter,prognosis was more worse.Expression of RIP1 was an independent bad prognosis predictor.Conclusions Expression of RIP1 in ESCC is high and maybe it participates in the pathogenesis of ESCC.