AS及MVD在子宫内膜癌组织中表达状况及临床研究

The expression of angiostatin and microvessel demist in endometrial and the clinical investigation

目的研究血管生长抑制素(AS)和微血管密度(MVD)在子宫内膜癌中的表达及临床应用价值。方法增生期子宫内膜组,子宫内膜增殖症组,子宫内膜癌组各30例,采用免疫组织化学法检测其子宫内膜组织中AS及MVD的表达结果。结果 (1)子宫内膜癌组与增生期子宫内膜组、子宫内膜增殖症组间MVD、AS间的差异有统计学意义(P<0.05);(2)血管抑素与MVD的表达有相关性(rs=0.706,P<0.05)。结论 AS和MVD在子宫内膜癌的发生发展中起到重要作用,可以考虑将它们看做子宫内膜癌的潜在侵袭性方面的肿瘤标志物,作为抗肿瘤治疗的新靶标。

Objective To investigate the expression and significance of angiostatin and microvessel demist in endometrial and the clinical investigation. Methods The immunohistochemical method was used to detect the expression of AS and microvessel demist in 30 adenocareinoma endometrial,30 endometrial hyperplasia and 30 endometrial cancer. Results First,the levels of MVD showed a significant difference between adenoearcinoma endometrial,endometrial hyperplasia and endometrial cancer（P 〈 0.05）;Second,the expression of angiostatin was associated with MVD （rs=0.706,P 〈 0.05）. Conclusion The results clue on the important role of AS and MVD on the development of endometrial earcinoma. Additional we can treat them as endometrial eareinoma potential invasive tumor markers and as the anti-tumor therapy of important novel targets.