奥美拉唑联合血凝酶治疗重型颅脑损伤的临床疗效观察

Clinical efficacy of omeprazole and hemocoagulase in the treatment of stress ulcer bleeding in severe traumatic brain injury

目的观察奥美拉唑与血凝酶联合治疗重型颅脑损伤应激性溃疡出血的临床疗效,寻找更为有效的治疗措施。方法 138例重型颅脑损伤应激性溃疡出血患者随机分为对照组69例,采用奥美拉唑等常规治疗;治疗组69例,在对照组基础上加用血凝酶胃管内注入。结果治疗组显效37例(53.6%)、有效14例(20.3%)、微效12例(17.4%)、无效6例(8.7%),总有效率91.3%;对照组显效27例(39.1%)、有效9例(13.0%)、微效7例(10.1%)、无效26例(37.7%),总有效率62.3%。两组疗效比较差异有统计学意义(P<0.001)。结论奥美拉唑与血凝酶联合使用对于治疗重型颅脑损伤应激性溃疡出血可以产生协同作用,治疗效果显著,值得临床推广。

Objective To find a more effective treatment measure by clinical observation on the therapeutic effect of omeprazole combined with hemocoagulase treating severe traumatic brain injury stress ulcer bleeding. Methods 138 cases of severe traumatic brain injury stress ulcer bleeding patients were randomly divided into 2 groups of 69 cases, and one group was control group took routine treatment by omeprazole. The other was treatment group which was injected hemoeoagulase by gastric tube influx in addition to routine treatment. Results 37 cases （53.6%） of treatment group were markedly effective,14 cases（20.3%） were effective, 12 cases （17.4%） were minor effective, 6 cases（8.7%） were ineffective, and the total effective rate was 91.3%; 27 cases（39.1%） of control group were markedly effective,9 cases（13.0%） were effective, 7 cases（10.1%） were minor effective,26 cases（37.7%） were ineffective, and the total effective rate was 62.3%. There was significant difference between the two groups （P 〈 0.001）. Conclusion Omeprazole and hemocoagu!ase have synergistic effects on treating severe traumatic brain injury stress ulcer bleeding, and it is of significant curative effect, so it＇s worthy of clinic application.