儿童哮喘的治疗及与肺炎支原体感染的相关性分析研究

Correlation analysis between treatment of childhood asthma and pneumonia mycoplasma infection

目的探讨儿童哮喘的治疗及与肺炎支原体感染的相关性。方法选择我院2011年3月～2013年1月收治的患儿180例,将患儿依据病情进行分组,符合儿童哮喘诊断标准患儿97例为哮喘组,符合肺炎诊断标准患儿83例为肺炎。两组患儿均经过常规治疗,哮喘组采用阿奇霉素进行治疗,剂量每次10mg/kg,每日1次,加入5%葡萄糖溶液进行静滴,7～14d为1个疗程。肺炎组采用先锋类抗生素进行治疗,对比两组患儿症状情况。在治疗之前两组患儿进行ELISA法检验血清中的抗MP-IgG、MP-IgM特异性抗体。结果哮喘组MP-PCR、IgM、IgG与肺炎组比较阳性率显著增高(P<0.01),哮喘组气促缓解、咳嗽小时、肺啰音消失缓解时间小于肺炎组(P<0.05)。结论哮喘与肺炎支原体感染具有相关性,阿奇霉素对此类患儿治愈率较高,且不良反应少,值得临床上广泛推广。

Objective To study the correlation between treatment of childhood asthma and pneumonia mycoplasma infection. Methods 180 cases of children in March 2011 - January 2013 treated in our hospital were chosen and divided according to the pathogenetic condition,97 cases consistent with asthma diagnostic criteria were for asthma group,83 cases of consistent with pneumonia diagnostic criteria were for pneumonia group. Two groups were both given conventional treatment,asthma group was treated with azithromycin, lO mg/kg every time,once a day,add 5% glucose solution for intravenous drip,7-14 d as a course of treatment. Pneumonia group were given xianfeng class antibiotic,compare the symptoms of two groups. Before treatment the serum MP-IgG and MP-IgM resistance specific antibody of two groups were inspected by ELISA method. Results The positive rate of MP-PCR,IgM and IgG in asthma group were significantly increased compared with pneumonia group（P 〈 0.01）,the relief and disappearance time of taehypnea,cough and lung sound of asthma group were less than pneumonia group（P 〈 0.05）. Conclusion Asthma is associated with myeoplasma pneumoniae infection,the cure rate of azithromycin for such children is higher,with less adverse reactions,worthy of clinical widely.