血浆B型脑钠肽诊断急性呼吸道感染合并心力衰竭患者临床价值探讨

Clinical value of BNP in the diagnosis of acute respiratory infection complicated with heart failure

目的探讨血浆B型脑钠肽在诊断急性呼吸道感染合并心衰患者中的临床价值。方法将我院收治的54例急性呼吸道感染患者,其中合并心衰25例(A组)、未合并心衰29例(B组),另选取体检正常者40例为对照组。记录比较A、B组患者治疗前后及对照组血浆BNP、TNF-α及IL-8水平,比较各组指标水平及变化情况。结果治疗前A、B组患者血浆TNF-α、IL-8及BNP水平均显著高于对照组(P<0.01),且急性呼吸道感染合并心衰患者(A组)血浆BNP水平显著高于未合并心衰患者(P<0.01);治疗后急性呼吸道感染合并心衰患者(A组)血浆BNP水平较治疗前明显下降(P<0.01)。结论血浆BNP水平可作为急性呼吸道感染患者合并心衰的诊断依据,对于临床快速、诊断并及时纠正急性呼吸道感染患者呼吸困难的病因具有重要意义。

Objective To investigate the clinical significance of BNP in the diagnosis of acute respiratory infection complicated with heart failure. Methods 54 cases of acute respiratory infections were divided into group A with 25 cases who were complicated with heart failure and group B with 29 cases who were not complicated by heart failure. Another 40 ones whose had normal physical examination were chosen as the control group. The plasma BNP, TNF- α and IL-8 levels in patients of group A and B with the control group before and after treatment were recorded and compared. Results The level of TNF-α, IL-8 and BNP of group A and group B were significantly higher than those in the control group （P 〈 0.01） while BNP level of group A was significantly higher than group B and control group（P 〈 0.01）. The BNP levels of group A decreased significantly after treatment （P 〈 0.01）. Conclusion BNP levels can be used as diagnostic evidence of acute respiratory tract infection in patients with heart failure.