氰基丙烯酸酯-纳米药物骨的靶向治疗

Cyanoacrylate-nano drug: A bone-targeted therapy

背景:以α-氰基丙烯酸酯为主体的医用胶黏剂经过改性研究,在湿性环境中能产生较大粘接强度,如承载不同种类的药物,利用其能在体内自然降解的性能,不仅可以实现药物的缓释,还可以诱导新生骨组织的爬行替代。目的:分析氰基丙烯酸酯和纳米给药系统各自的理化特性及优缺点,阐明其将来的临床应用前景及尚待解决的问题。方法:检索PubMed数据库、中国期刊全文数据库2004年1月至2012年10月有关氰基丙烯酸酯和纳米药物骨靶向治疗的文献,检索英文关键词为"Cyanoacrylate;nanoparticle drug delivery system;Targeted therapy",中文关键词为"氰基丙烯酸酯;纳米给药系统;靶向治疗"。结果与结论:将氰基丙烯酸酯黏合胶复合纳米药物进行骨靶向治疗,是鉴于氰基丙烯酸酯及其衍生物具有在骨髓腔等湿性条件下能迅速黏合,强度较大,能生物降解等诸多优点。FDA已将氰基丙烯酸酯的适用级别从Ⅲ级提升至Ⅱ级,今后的课题若能充分利用纳米药物靶向治疗的特点优势,实现药物的高载荷和药物控释,通过交叉学科的互相渗透,针对提高骨-假体界面黏合强度、生物力学强度和弹性模量,研发复合型生物材料,改善单一材料在性能上的缺陷,靶向长效纳米药物黏合胶将是治疗骨肿瘤、骨结核和骨髓炎等疾病的一种重要手段。

BACKGROUND： Modified medical adhesives with a-cyanoacrylate as the main component can produce a large adhesive strength in a moist environment, such as carrying different types of drugs, achieving a sustained release of drug and inducing the creeping substitution of new bone tissue. OBJECTIVE： To analyze the physical and chemical characteristics of cyanoacryiate-nano drug delivery system so as to ctarify its clinical prospect in the future and problems to be solved, METHODS： A computer-based online search of PubMed, CNKI databases was performed for articles published from January 2004 to October 2012 using the key words of ＂cyanoacrylate; nanoparticle drug delivery system; targeted therapy＂ in English and Chinese, respectively. Articles related to cyanoacrylate and nano-drugs bone targeted therapy were included. RESULTS AND CONCLUSION： In view of cyanoacrylate and its dedvat!ves can be bonded quickly in the bone marrow cavity under moist conditions, have larger strength and can be dgraded, cyanoacrylate-nano drug is used for bone targeted therapy. The FDA has upgraded cyanoacrylate applicable level from Class Ⅲ to Class Ⅱ Future issues could make full use of the advantages of nano-drug targeted therapy, to achieve high drug load and controlled drug release; carry out interdisciplinary research to improve bonding strength, biomechanical strength and elastic modulus of bone-prosthesis interface; develop composite biomaterials thereby to improve the deficiency of single materials in performance. Compound nano-drug targeted therapy will be a great potential way to the treatment of bone tumors, bone tuberculosis and osteomyelitis.