周围型肺癌64层螺旋CT征象、病理分型与CCR7表达相关性研究

Studies on the correlation between the 64-slice CT features,pathologic classifications and expression of CCR7 in peripheral lung cancer

目的探讨周围型肺癌CT征象与CCR7(CC chemokine receptor 7,CC类趋化因子受体7)表达的关系。方法收集资料完整并经手术、病理证实的周围型肺癌26例。全部患者术前均行64层螺旋CT平扫及增强扫描,术前未进行放射治疗或化疗。应用免疫组织化学染色(MaxVisionTM二步法)检测26例周围型肺癌中CCR7的表达水平,并将肺癌的CT征象与CCR7免疫组化检测结果进行比较,检测所得数据用SPSS 17.0统计软件包进行分析,率的比较用fisher精确概率法,P<0.05为差异有统计学意义。结果①周围型肺癌中,CCR7表达在腺癌中阳性表达率75.0%(15/20),鳞状细胞癌33.3%(2/6),P<0.05,差异有统计学意义;②CCR7在肿瘤≤3.0cm者阳性表达率75.0%(15/20),而>3.0cm者仅33.3%(2/6),P<0.05,差异有统计学意义;③CCR7表达与瘤体深分叶征、棘状突起、空泡征、胸膜凹陷征、毛刺征、纵隔淋巴结转移等CT征象无关(P>0.05)。结论周围型肺癌CCR7的阳性表达与病理类型有关,与有诊断价值的CT征象无关。

Objective To explore the expression relationship between 64-slice CT features and the CCR7 （CC chemokine receptor 7） in peripheral lung cancer. Methods The data of 26 cases of peripheral lung cancer confirmed by operation and pathological classifications were clected. All patients had MSCT scan before operation, and without radiotherapy or chem- otherapy. The expression of CCR7 was examined by means of SP immunohistochemical technology （Max Vision TM） in the 26 patients, and compared with the 64-slice CT features of lung cancer with the CCR7 immunohistochemical test resuits, data was analysed by SPSS 17.0 statistical software, the rate was compared with fisher exact method test, P d0.05 and the difference was statistically significant. Results （D The expression of CCR7 in the adenocarcinoma with positive expression rate was 75.0% （15/20）, and in squamous cell carcinoma the positive expression rate was 33.8% （2/6）, in the peripheral lung cancer, P 〉0.05, the difference was statistically significant; The expression of CCR7 in the cancer size of 43.0 cm the positive expression rate was 75.0% （15/20）, and in the cancer size of 3.0 cm the positive expression rate was 33.3% （2/6）, P 〈0.05, the difference was statistically significant; It was not associated between the expression of CCR7 and CT signs of the tumor deep lobulation, spieulate protuberance, vacuole sign, pleural indentation, spiculation, mediastinal lymph node metastasis, （ P 〉0. 05）. Conclusion The positive expression of peripheral lung cancer of CCR7 is related to pathologic type, not associated with the diagnostic CT features.