悬钩子木对实验性慢性支气管炎的影响

Studies on chronic bronchitis with Ramulus rubi

目的:探讨蒙药材悬钩子木治疗慢性支气管炎的药理作用。方法:用"香烟熏法"建立慢性支气管炎小鼠模型后灌胃给悬钩子木的水提取物14天,测定体重变化、计算肺指数及肺组织病理学改变。结果:模型对照组支气管上皮细胞变形、坏死、脱落,支气管管腔内见有渗出物,肺泡扩张,呈肺气肿变化。悬钩子木大剂量组、中剂量组及阳性对照组肺宁颗粒都明显减轻小鼠肺组织病理改变。结论:悬钩子木水提取物的高剂量组(8.56g/kg)、中剂量组(4.28g/kg)、小剂量组(2.14g/kg)均不同程度减轻小鼠肺组织病理改变,可能具有治疗慢性支气管炎的作用。

To explore pharmacological action of Mongolian Medicine Ramulus Rubi to treat chronic bronchitis. Methods： Cigarette-smoking is used to establish chronic bronchitis model of the mice. The water extracts of Ramulus Rubi was perfused into the stomach of the mice for 14 days, and then body weight change, the lung index and pathological changes were tested. Results： In model control group, cell deformation necrosis and loss occurred in bronchial epithelial cells. There are exudates in bronchial lumen. The expansion of the alveoli and emphysema can be observed. Ramulus Rubi high-dose group, middle-dose group and positive control all relieved significantly the inflamma- tion of lung tissue in infected mice, but treatment impact of low-dose group is not significant. Conclusion： The water extracts of Ramulus Ru- bi can relieve the inflammation of lung tissue and have pharmacological action to treat chronic bronchitis.