黄蜀葵花总黄酮对麻醉犬血流动力学及心肌耗氧量的影响

Effects of Total flavone of Abelmoschus manihot(L.) Medic on hemodynamics and myocardial oxygen consumption in anesthetized dogs

目的:研究黄蜀葵花总黄酮(TFA)对麻醉犬血流动力学及心肌耗氧量的影响。方法:杂种犬30只,人工呼吸下开胸,给药后观察其心率(HR)、血压(MAP)、心输出量(CO)、冠脉血流量(CBF)、左室压(LVP)及血氧含量,计算冠脉阻力(CVR)和体循环总外周阻力(TPR)等血流动力学指标,采用多普勒超声血流仪测定麻醉犬冠脉流量和心输出量,用血气分析仪测定血氧含量。结果:黄蜀葵花总黄酮60、30mg/kg能增加犬冠状动脉和主动脉的血流量、增加每分钟100克心肌血流量及心搏出量;提高心搏指数及心脏指数;降低左室内压、左室舒张末期压、总外周血管阻力和冠脉阻力。结论:黄蜀葵花总黄酮可明显改善麻醉犬血流动力学参数。

Objective：To investigate the effects of Total flavone of Abelmoschus manihot（L.） Medic（TFA） on hemodynamics and myocardial oxygen comsumption in anesthetized dogs.Methods： In 30 dogs with artificial ventilation,the changes in parameters at different time were observed,such as heart rate（HR）,mean arterial p ressure（MAP）,coronary blood flow（CBF）,cardiac output（CO）,left ventricular p ressure（LVP） and blood oxygen content.The hemodynamic parameters,coronary vascular resistance（CVR）,total peripheral resistance（TPR）,stroke volume（SV）,stroke index（SI）,cardiac index（CI）,left ventricle stroke work index（LVWI） and myocardium oxygen consumption index（MOCI）,were calculated.Coronary artery blood flow and cardiac output were measured by Doppler flow meter.Blood oxygen content was determined by oximeter.Results： TFA could significantly decline the HR and LVP,but could not change MAP.TFA could significantly increase coronary artery blood flow and cardiac output,reduce cerebral vascular resistance,total peripheral resistance and coronary vascular resistance,increase cardiac index,stroke index,stroke volume and decline myocardium oxygen consumption index.Conclusion： Total flavone of Abelmoschus manihot（L.） Medic can improve the parameters of hemodynamics in anesthetized dogs.