含肟酯类姜黄素衍生物的合成及抗肿瘤活性研究

Synthesis of oxime-esters of curcumin derivatives and their anti-tumor activities

采用生物活性因子拼接的方法将肟酯引入单羰基姜黄素衍生物1,5-二取代芳基-1,4-戊二烯-3-酮化合物中,通过醚化、肟化、酰化,最后酯化合成11个不对称1,5-二取代-1,4-戊二烯-3-酮肟酯类姜黄素衍生物,其结构经IR、1 H NMR和元素分析确证.初步生物活性测试结果表明,部分化合物具有一定的体外抗肿瘤活性.

Curcumin was modified by active functional group oxime ester with biologically active factor splicing of 1,5-diphenyl-1,4-pentadien-3-one compound. Eleven novel compounds were synthesized through etherification, oximic reaction and esterify reaction. The structure was identified by IR, a H NMR spectra and element analysis. The preliminary bioassay showed that some of the compounds ex- hibited a certain inhibitory activity of anti-tumor.