壳聚糖嫁接大环席夫碱Cu(Ⅱ)配合物的合成及其抗氧活性研究

Preparation of chitosan grafted with Cu(Ⅱ)-complexes of macrocyclic Schiff Base and evaluation of their antioxidant activity

制得了系列壳聚糖嫁接的大环席夫碱Cu(Ⅱ)化合物(CTS-Ln-Cu(Ⅱ).通过元素分析、1 H NMR、FT-IR、MS及扫描电镜(SEM)等手段对上述化合物的结构和组成进行了表征.并采用邻苯三酚自氧化法测定了它们的抗氧活性.结果表明,经过嫁接后均具有良好的抗氧活性,其IC50值分别为:15.81,18.82,21.44和19.33×10-3 g.L-1.

A serial of the chitosa grafted with Cu（II ）-complexes （CTS-Ln-Cu（ II ））macrocyclic Schiff base have been synthesized and characterized by elemental analysis,ill NMR, IR, MS spectra and scanning electron micrograph（SEM）. The activity of mimicking superoxide dismutase of the comple- xes was determined by autoxidation of 1,2,3-benzenetriol. It was found that the the chitosa grafted with macrocyclic Schiff base complexes（CTS-Ln-Cu（ II ）） had good antioxidant activity, and with IC50 values of 15.,81,18.82,21.44 and 19.33×10^-3g·L^-1 ,respectively.