口服避孕药联合二甲双胍治疗多囊卵巢综合征的对照研究

Comparative study of the combination of oral contraceptives caplendus and metformin in the treatment of polycystic ovary syndrome

目的探讨口服避孕药(达因-35)联合二甲双胍治疗多囊卵巢综合征(PCOS)的临床疗效。方法 2010年1月至2012年1月在阜阳市人民医院就诊的PCOS患者120例,随机分为A、B两组。A组62例,应用达因-35联合二甲双胍治疗;B组58例,单用达因-35治疗,疗程均为3个月。结果 A、B两组临床症状改善情况比较差异无统计学意义(P>0.05)。A组治疗后睾酮(T)、黄体生成素(LH)、LH/卵泡刺激素(FSH)明显下降(P<0.05);B组治疗后T、LH、LH/FSH明显下降(P<0.05),腰臀比和体质量指数明显增加(P<0.05)。结论口服避孕药联合二甲双胍是治疗PCOS的最佳选择。

Objective To investigate the therapeutic effects of the combination of oral contraceptives caplendus（diane-35） and metformin on patients with polycystic ovary syndrome.Methods One hundred and twenty PCOS patients in Fuyang people’s hospital were randomly divided into two groups： group A and B.Sixty-two patients in group A were treated with the combination of diane-35 and metformin,while 58 patients in group B were just treated with diane-35,the period of treatment was three months.Results After three months of treatment,there were no significant differences of the clinical features improvement（P＆gt;0.05）;T,LH and LH/FSH ratio decreased significantly in group A and B（P＆lt;0.05）,WHR and BMI level of group B showed significant improvement,there were significant differences（P＆lt;0.05）.Conclusion Combined using diane-35 and metformin in the treatment of PCOS is the best therapeutic method.