摘要
目的观察心房颤动(AF)患者白细胞介素-18(IL-18)血清水平的变化,探讨炎症与AF的关系。方法入选阵发性AF患者36例,持续性AF患者52例及30例年龄、性别与AF组匹配的但无AF人群作为对照组,采用ELISA法检测血清IL-18水平、免疫比浊法测超敏C-反应蛋白(hs-CRP)水平。结果持续性AF组血清IL-18、hs-CRP较对照组和阵发性AF组均升高(P<0.05)。阵发性AF组血清IL-18、hs-CRP较对照组升高(P<0.05)。AF患者血清IL-18水平与hs-CRP水平具有显著正相关性(n=88,r=0.638,P<0.05)。结论 AF患者血清IL-18水平显著升高。AF与炎症有关,炎症参与了AF的发生和发展。
Objective To observe the change of interleukin-18 （IL-18）in patients with atrial fibrillation so as to explore the correlation between inflammation and atrial fibrillation. ,Methods A total of 88 consecutive AF patients（paroxysmal AF group included 36 cases, persistent AF group included 52 cases） were enrolled in this study.Thirty ageand sexmatched people without AF were considered as control group. The serum IL-18 and hs-CRP content of each group was measured respectively by ELISA and immune turbidimetry. Results The serum level of IL-18 in the persistent AF groupwas higher than that in the paroxysmal AFgroup and the control group（both P〈0.05）; The serum level of IL-18 in the paroxysmal AF group was higher than that in the control group（P〈O.05）. There was significantly positive correlation between IL-18 and hs-CRP in AF patient（n=88, r=0.638, P〈O.05）. ConclusionS The serum level of IL-18 is markedly increased in AF patients.The result indicates that inflammation may play an important role in the genesis and sustaining of AF.
出处
《中国实用医药》
2013年第17期5-7,共3页
China Practical Medicine
