艾司西酞普兰治疗酒依赖伴抑郁及焦虑临床观察

Clinical observation on escitalopram in treating alcohol dependence complicating depression and anxiety

目的了解艾司西酞普兰治疗酒依赖伴抑郁及焦虑的临床疗效。方法将46例患者随机分为研究组和对照组各23例。研究组在常规戒酒的基础上联合应用艾司西酞普兰治疗,对照组予以常规戒酒治疗,两组患者在治疗前,治疗2、4、6周采用汉密尔顿抑郁量表(HAMD-17)、焦虑量表(HAMA)进行评分,并在治疗前,治疗1、2、3个月用乙醇依赖程度问卷进行评分。结果治疗1周后HAMD-17评分显示,研究组治疗前后比较,差异有统计学意义(t=2.30,P<0.05),对照组治疗前后比较,差异无统计学意义(t=0.82,P>0.05);在治疗第2、4、6周时,研究组评分均明显低于对照组(P<0.05)。治疗1周后HAMA评分显示,研究组治疗前后比较,差异有统计学意义(t=2.56,P<0.05),对照组治疗前后比较,差异无统计学意义(t=1.82,P>0.05)。治疗1、2、3个月时乙醇依赖程度问卷评分显示,研究组治疗后均低于对照组(P<0.05或0.01)。结论伴抑郁及焦虑的酒依赖患者,服用艾司西酞普兰能改善其抑郁情绪,降低患者对酒的依赖程度。

Objective To explore the clinical efficacy of escitalopram in the treatment of alcohol dependence complicat- ing depression and anxiety. Methods 46 patients with alcohol dependence were randomly divided into two groups. The research group was administered with escitalopram on the basis of routine alcohol temperance ,while the control group was given the rou tine alcohol temperance.The effects were evaluated with the Hamilton Depressive Scale （HAMD-17 ） and the Hamilton Anxiety Scale （HAMA） before treatment and in 2,4,6 weeks after treatment. The alcohol dependence degree questionnaires were con- ducted before treatment and in 1,2,3 months after treatment. Results After 1-week treatment,the soeres of HAMD-17 in the re search group showed statistical difference compared with before treatment（t=2.30,P〈0.05）,but there was no statistical differ- ence in the control group （t=0.82 ,P〉0.05）, and the score of HAMD-17 in the research group was more obvious than that in the control group in 2,4,6 weeks after treatment. The HAMA socres after treatment in the research group showed statistical differ- ence compared with before treatment （t=2.56, P〈0.05 ）, but there was no statistical difference before and after treatment in the control group （t=1.82 ,P〉0.05 ）. The scores of alcohol dependence degree questionnaires at 1,2,3 month treatment in the research group were lower than those in the control group （P〈O.05 or 0.01 ）. Conclusion Escitalopram may improve the depression and anxi ety symptoms, and decrease the level alcohol dependence in the patients with alcohol dependence complicating depression and anxiety.