感音神经性耳聋者的脑灰质结构基于体素形态学的研究

Voxel-based Morphology Study of Sensorineural Hearing Loss Patients

目的利用基于体素形态学技术分析听力正常人志愿者与感音神经性耳聋患者之间的脑灰质差异。方法分别对24例听力正常人及24例感音神经性耳聋人进行常规T2-WI与三维(3D)快速扰相梯度回波(fast spoiled gradient echo,FSPGR)采集脑结构图像。用VBM技术运算,然后观察两组之间的脑质差异并显示出差异脑区的MNI坐标及差异容积,然后对所得数据进行相应统计学分析。结果感音神经性耳聋组脑灰质增多的区域有(P<0.01,Cluster size=40):左侧颞上回、右侧颞上回、左侧额下回、左侧中央前回、左侧中央后回、左侧扣带回、左侧小脑半球、左侧顶下小叶、左侧屏状核、左侧小脑前叶、右侧小脑前叶、右侧小脑后叶、右侧额下回。结论感音神经性聋人在左、右侧颞上回灰质增多,提示其听觉中枢皮质有结构重组。

Objeetive To comparied the cerebral gray matter of the normal hearing subjects and the sensorineural deafness patients with voxel-based morphology. Methods Both the normal hearing group and the sensorineural deafness group were scaned with GE 3.0T MRI scaner to get routine T2WI and three-dimensional （3D） fast spoiled gradient echo （fast spoiled gradient echo, FSPGR） collection of brain structures image. Observed qualitative differences of the brain with VBM between the two groups and demonstrate the differences between the MNI coordinates of brain regions and the differences in volume, and then statistically analyzed the data accordingly. Result The increasing areas of gray matter in sensorineural hearing loss patients（P〈 0.001,Cluster size=50）： the left superior temporal gyms, right superior temporal gyms, left inferior frontal gyrus, left precentral gyms, left, after the central back, left cingulate gyms, left lateral cerebellar hemispheres, the left wedge leaf, the left inferior p^ietal lobule, the left claustrum, the left cerebellar anterior lobe, right cerebellar anterior lobe, right behind the small leaf, the right inferior frontal gyms. Conclusion The increased gray matter of Sensorineural deaf are in the left and right superior temporal gyms, indicating its structural reorganization of auditory cortex.