摘要
目的检测MMP-1与脂蛋白(a)在急性冠脉综合征(ACS)患者外周血中浓度的变化,探讨其临床意义。方法采用酶联免疫吸附法(ELISA)及免疫透射比浊法测定72例ACS患者、45例稳定性心绞痛(SAP)患者和53例健康对照者血浆MMP-l及脂蛋白(a)水平,比较三组之间MMP-1及脂蛋白(a)血浆水平的差异,Lp(a)与MMP-1血浆水平之间的关系。结果血浆MMP-l及脂蛋白(a)水平在ACS组高于SAP组和对照组(P<0.05),MMP-1血浆水平与LP(a)在ACS组呈显著正相关,(r=0.412,P<0.01)。结论血浆MMP-l、Lp(a)水平升高与ACS密切相关,二者在ACS的发病过程中可能存在相互作用。
Objective To study changes of the levels of serum MMP-1 and LP （a） of patients with acute coronary syndrome（ACS）. Method We selected 72patients with acute coronary syndrome （ACS）, 45 patients with stable angina pectoris （SAP）, 53 patients without coronary heart disease were as the conlrol group, using enzyme-linked immunosorbent assay （EL1SA） method to determine the plasma level of MMP-1; using transmission turbidim- etry to determine plasma level of LP （a）. The plasma levels of MMP-1 and Lp （a） in each group was compared,Analysis the relationship between MMP-1 and Lp （a）. Results The plasma levels of MMP-1 and Lp （a） in ACS group was significantly higher than the SAP group and control group, P〈0.05; there is a significantly positive correlation between plasma levels of MMP-1 and LP （a） in ACS group, （r=0.412, P〈0.01）. Conclusions The higher plasma levels of MMP-1 and LP （a） are closely associated with ACS. LP （a） and MMP-1 are interact on each other in the pathogenesis of ACS.
出处
《中国医药指南》
2013年第16期37-38,共2页
Guide of China Medicine
