雷贝拉唑四联疗法治疗幽门螺杆菌感染消化性溃疡的临床观察

Clinical Observation of Rabeprazole Quadruple Therapy Treatment of Helicobacter Pylori Infection Peptic Ulcer

目的观察雷贝拉唑四联疗法治疗消化性溃疡的疗效及对HP感染的根除率。方法选择我院经胃镜检查确诊及14C尿素呼气试验阳性的64例消化性溃疡患者,随机分为治疗组和对照组各32例,治疗组给予雷贝拉唑10mg 2次/d,阿莫西林1000mg 2次/d,呋喃唑酮100mg 2次/d、果胶铋150mg 3次/d,疗程7d,果胶铋再加服1周,然后单独给予雷贝拉唑20mg 1次/d继续治疗;对照组:果胶铋150mg 3次/d、阿莫西林1000mg 2次/d、呋喃唑酮100mg 2次/d,疗程7d,后单独给予果胶铋150mg 3次/d;两组总疗程十二指肠溃疡DU4周,胃溃疡GU6周,疗程结束后复查胃镜及HP以评价疗效。结果两组主要症状的变化及腹痛消失时间比较,差异有统计学意义(P<0.05);治疗组和对照组总有效率分别为96.88%、78.13%,两组比较差异有统计学意义(P<0.05);治疗组和对照组HP根除率分别为93.75%、71.88%,两组比较差异有统计学意义(P<0.05);治疗组和对照组不良反应率分别为3.13%和3.13%,差异无统计学意义。结论雷贝拉唑、阿莫西林、呋喃唑酮、果胶铋四联疗法能明显缓解消化性溃疡的症状,止痛效果快,不良反应少,对消化性溃疡有较高的治愈率及HP感染的根除率。

Objective to observe the rabeprazole quadruple therapy treatment of peptic ulcer and effect on helicobacter pylori infection eradication rate. Methods choose from the gastroscopy confirmed and 14C urea breath test positive of 64 cases of peptic ulcer patients, random divided into treatment group and control group, the 32 cases of the treatment group was given rabeprazole, amoxicillin, furazolidone, pectic bismuth, 7 days treatment, pectic bismuth plus take 1 week, then separate give rabeprazole to continue treatment; Control group; bismuth pectin, amoxicillin, furazolidone 7 days after treatment, alone give pectic bismuth; Two groups of total treatment duodenal ulcer,DU 4 weeks, gastric ulcer GU 6 weeks, after the treatment the gastroscope and helicobacter pylori to evaluate curative effect. Results two groups of main symptoms change and abdominal pain disappeared time is, the difference was statistically significant （P〈0.05）; The treatment group and the control group total effective rate was 96.88% and 78.13%, respectively, between the two groups （P〈0.05）; The treatment group and the control group HP eradicate rate was 93.75% and 71.88%, respectively, between the two groups （P〈0.05）; The treatment group and the control group adverse reaction rate were 3.13% and 3.13% respectively, the difference was not statistically significant. Conclusion rabeprazole, amoxicillin, furazolidone, pectic bismuth quadruple therapy can obviously alleviate the symptoms of peptic ulcer, analgesic effect fast, fewer side effects, peptic ulcer have higher cure rate and the rate of helicobacter pylori infection.