摘要
An efficient and mild synthesis of 2-（guaiazulen-l-yl）furans, starting from easily accessible 1-（3-aryl-2- cyanopropenoyl）guaiazulenes, tributylphosphine and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to append the crucial furan ring, leading to the highly functional furans in good yields.
An efficient and mild synthesis of 2-（guaiazulen-l-yl）furans, starting from easily accessible 1-（3-aryl-2- cyanopropenoyl）guaiazulenes, tributylphosphine and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to append the crucial furan ring, leading to the highly functional furans in good yields.
基金
the Science and Technology Department of Liaoning Province(No.2011220022)
the Innovation Talent Program of Heilongjiang University of Chinese Medicine for financial support
