综合干预治疗对高泌乳素不孕患者的影响研究

Study of impact of comprehensive intervention on the infertility patients with high prolactin

目的:探讨综合干预治疗对降低不孕患者职业紧张程度及血泌乳素(PRL)的效果。方法:2011年1月至2012年6月对门诊就诊的不孕患者282例进行问卷调查,月经后2～4 d进行PRL测定,随机将患者分为治疗组(141例)与对照组(141例),对照组采用单纯常规药物治疗,治疗组在药物治疗基础上给予职业紧张群体干预措施,连续治疗6个月,观察治疗后PRL变化及对受孕率的影响。结果:治疗组不孕患者职业紧张评分中职业任务评分(ORQ)、个体紧张反应评分(PSQ)明显下降,应对资源评分(PRQ)明显上升,PRL水平明显下降,与对照组比较差异有统计学意义(P<0.01),治疗组6个月妊娠率为29.08%(41/141),明显高于对照组12.77%(18/141),差异具有统计学意义(P<0.01)。ORQ、PSQ与PRL升高呈正相关;PRQ与PRL增高呈负相关。结论:对高PRL不孕患者进行综合干预治疗可降低职业紧张程度,能够降低PRL水平,提高受孕率。

Objective： To investigate the effects of the comprehensive intervention to reduce occupational stress level and blood prolactin（PRL） in the infertility patients with high prolactin.Methods： Two hundred and eightytwo infertility patients with high PRL from January 2011 to June 2012 were researched,and prolactin was determinated 2-4 days after menstruation.Patients were randomly divided into treatment group（141 cases） and the control group（141 cases）.Patients in the control group received simple conventional drug treatment,patients in the treatment group received comprehensive intervention on the basis of drug treatment,and then the PRL changes and the impact of the pregnancy rate were observed at 6 months after continuous treatment.Results： Occupational stress score of infertile patients in the treatment group about occupational tasks rating（ORQ）,individual stress response score（PSQ） decreased,coping resources score（PRQ） significantly increased,PRL levels decreased significantly,compared with the control group,there was statistically difference（P 0.01）.Six months after treatment,the pregnancy rate in the treatment group was 29.08%（41 /141）,significantly higher than 12.77%（18 /141） in the control group,and there was statistically difference（P 0.01）.ORQ,PSQ were positively correlated to PRL;PRQ was negatively correlated to PRL.Conclusion： Comprehensive intervention in the infertility patients with high PRL can reduce occupational stress and PRL levels,and improve the pregnancy rate.