颈复康颗粒治疗神经根型颈椎病的系统评价

Systematic Review of Jingfukang Keli for the Treatment of Nerve Root Cervical Spondylosis

目的运用系统评价颈复康颗粒治疗神经根型颈椎病的有效性及安全性,了解颈复康颗粒治疗神经根型颈椎病的临床疗效以及可应用性。方法采用Cochrane系统评价方法,电子检索MED-LINE、EMBASE、Cochrane图书馆临床对照试验资料库、中国生物医学文献数据库、中国期刊全文数据库、重庆维普数据库、万方数据库,由两名评价员独立评价文献质量、提取资料并交叉核对,而后采用RevMan 5.2软件进行Meta分析。结果 3项研究,共696例患者纳入本次研究。3项研究均以有效率作为主要结局指标。对同质性较强的研究进行Meta分析,显示证据证明颈复康颗粒组对照其他保守疗法组总有效率的Meta分析(OR=5.85,95%CI=3.27、10.46,Z=5.96,P<0.01),颈复康颗粒组对照牵引组总有效率的Meta分析(OR=20.20,95%CI=4.65、87.72,P<0.01),颈复康颗粒组对照美洛昔康分散片组总有效率的Meta分析(OR=2.44,95%CI=0.64、9.31,P=0.19),颈复康颗粒对照根痛平颗粒组总有效率的Meta分析(OR=3.62,95%CI=1.73、7.59,P=0.000 6)。结论目前纳入研究初步显示颈复康颗粒治疗神经根型颈椎病安全,在改善症状、提高整体功能等方面均优于对照组。但由于纳入研究存在选择性偏倚和测量性偏倚的高度可能性,势必影响结果的论证强度,因此临床研究质量有待提高。

Objective To evaluate the efficacy and safety of Jingfukang Keli in the treatment of Nerve Root Cervical Spondylosis and understand its applicability. Methods MEDLINE, EMBASE, The Cochrane Library, PubMed,VIP, CNKI and CBM were retrieved to identify randomized controlled trials of J ingfukang Keli versus the control in the treatment of Nerve Root Cervical Spondylosis. Quality assessment and data extraction were conduc- ted by two reviewers independently. Disagreement was resolved through discussion. All data were analyzed using RevMan 5.2 software. Results Three studies,total of 696 cases were enrolled. Effective rate was used as primary outcome measure in all three studies. Meta-analysis show that Jingfukang Keli was superb to the other therapies （OR=5.85,95% CI=3.27,10.46,Z=5.96,P〈0 is no significant advantage（OR= 2.44 reactions were reported. Conclusion ,95% C I = 064,9.31, P = 0. 19） spondylosis. However,due to a high risk Jingfukang of selectio 01）. To compares Jingfukang Keli with western medicine, there . No significant adverse effects or Allergic Keli is effective in the treatment of nerve root cervical n bias and detection bias in the included studies, the evidence isinsufficient to determine the effect of Jingfukang Keli . Further large-scale trials are required to define the role of Jingfukang Keli in the treatment of nerve root cervical spondylosis.