强化胰岛素控制血糖对重度颅脑外伤的效果分析

Efficacy analysis on treating severe brain injury with intensive insulin for control the blood sugar

目的:讨论在重度颅脑外伤患者治疗中,应用强化胰岛素控制血糖,对治疗和预后的意义。方法:选择80例重度颅脑外伤患者(排除患有原发糖尿病或其它影响糖代谢疾病的患者),分为强化控制组和正常控制组,各40例;其它治疗方法相同,强化控制组加大胰岛素浓度,控制血糖值在4.5～6.5mmol/L,正常控制组胰岛素用量正常,血糖值控制在8.5～11.0mmol/L,比较两组的疗效和预后。结果:强化控制组与正常控制组相比,治疗的总有效率更高,并发感染率和死亡率更低,P<0.05,有统计学意义。强化控制组平均呼吸机使用天数、抗生素类药物使用天数和住院天数比正常控制组少,P<0.05,有统计学意义。两组低血糖发生率无明显差异,P>0.05,无统计学意义。结论:在重度颅脑外伤患者的救治过程中,积极控制血糖,对改善患者的病情,减少感染,降低死亡率和提高疗效上,有积极的意义,值得临床学习推广。

Objective： To investigate the significance of treatment and prognosis in treating severe brain injury with intensive insulin for control the blood sugar. Methods： 80 patients with severe brain injury were divided into the strengthen control group and the normal control group, 40 for each group. The strengthen control group increased insulin to control blood sugar value in 4.5-6.5mmol/L. The normal control group was given normal amount of insulin, blood sugar control in the 8.5-11.0mrnol/L. The efficacy and prognosis were compared between the two groups. Results： The total efficiency of the treatment was higher in the strengthen control group, concurrent infection rate and mortality rate were lower than the normal control group, P〈0.05, the differentce was statistically significant. The average days of respirator application and antibiotic application were less than the normal control group, P〈0.05, the differentce was statistically significant. With both groups the incidence of hypoglycemia was no significant difference, P〉0.05, not statistically significant. Conclusion： Actively control the severe brain injury patients＇ blood sugar could improve the condition and efficacy of the patients, has positive significance, worthy of a wide clinical application.