影响宫腔内人工授精周期妊娠率的相关因素分析

Intra-uterine insemination:an evaluation of pregnancy rate and factors affecting outcome

目的分析影响宫腔内人工授精周期妊娠率的相关因素,以提高IUI治疗的临床效果。方法回顾性分析我院生殖科近5年来1224个宫腔内人工授精周期,探讨患者年龄、不孕原因、周期方案、精子回收率、排卵前卵泡直径、卵泡数目、卵泡是否破裂、子宫内膜形态与厚度、出血、漏出、授精次数等因素与妊娠率的关系。结果总妊娠率为12.6%(154/1224),logistic回归分析提示周期方案(OR:1.63,CI:1.10～2.41),精子回收率(OR:0.66,CI:0.46～0.96),卵泡是否破裂(OR:0.55,CI:0.28～0.91)显著影响IUI周期妇女妊娠率。结论促排卵及高精子回收率能提高IUI周期妊娠率,子宫内膜形态与厚度不影响妊娠率。

Objective：To analysis the relevant factors which affect the pregnancy rate in IUI cycles.Methods：1224 IUI cycles from Jan 2006 to Dec 2011 were included,female age,infertility duration,cause of infertility,cycle protocol,sperm recovery rate,middle follicle dominant,the type and thickness of endometrium,bleeding,leak and so on as the relevant factors were analysised.Results：The overall pregnancy rate was 12.6%（154/1224）,Logistic regression analysis revealed three predictive variables as regards pregnancy：cycle protocol（OR：1.63,CI：1.10~2.41）,sperm recovery rate（OR：0.66,CI：0.46~0.96）,follicle rupture or not（OR：0.55,CI：0.28~0.91）.Pregnancy rate did not have any independent relation to female age,infertility duration,cause of infertility,middle follicle dominant,the type and thickness of endometrium,bleeding,leak.Conclusion：Our results indicate that ovarian induction,high sperm recovery rate,follicle rupture were crucial factors that affected IUI pregnancy rate.