厦门地区男性不育患者精液和血细胞染色体核型分析

Analysis on sperm quality and chromosome of infertile males in Xiamen Area

目的探讨厦门地区男性不育与精液质量和染色体异常的关系。方法对800例男性不育患者进行精液质量和外周血淋巴细胞染色体核型分析。结果不孕组精子密度、前向运动率、正常形态精子百分率和DNA断裂指DFI与对照组相比,差异有统计学意义(P<0.05);染色体异常总数占75例,异常发生率达9.375%。性染色体异常57例,占异常总数的76%,常染色体异常18例,占异常总数的24%。结论精液异常和染色体异常是导致男性不育的重要原因,对男性不育患者进行精液质量和染色体核型分析是有必要的。

Objective： To explore the relationship between male infertility and sperm quality and chromosome abnormality in Xiamen Area.Methods： Sperm quality and chromosome of infertile males in Xiamen Area were examined.Results： A significant difference in the concentration and forward mobility and the percentage of normal sperm morphology and DFI of sperm between the recurrentm iscarriage group and normal fertility group（P 0.05）;The total number of abnormal chromosomes is 75 cases（9.375%）.The number of abnormal sex chromosomes is 57cases,accounting for 76% of the total abnormal chromosomes,while the number of abnormal euchromosomes is 18,accounting for 24%.Conclusions： Sperm quality and chromosome abnormality are important on male infertility,analysis of chromosome karyotypes and sperm quality is necessary to patients with male infertility.