O血孕妇血清IgG抗体与新生儿ABO溶血病的相关研究

Study for serum IgG antibody of pregnancies with O blood type and ABO hemolytic disease of the newborn

目的探讨152例0型血孕妇血型抗体效价与新生儿溶血病(HDN)发生的关系。方法根据O型孕妇妊娠16～32w测定的IgG抗A(B)效价,将其分成4组(≤1∶32,1∶64,1∶128,≥1∶256),比较分析各组新生儿溶血病的发生率。对部分效价过高者采取中药治疗的处理,比较分析其疗效。结果新生儿ABO溶血的发生率与母亲抗体效价相关,效价越高,新生儿溶血病发生率越高,差异有显著性(P<0.05)。孕妇IgG抗A(B)效价过高采取中药治疗一定程度上降低了新生儿溶血病发生率,但差异无显著性(P>0.05)。结论 O型孕妇血清IgG抗体与新生儿ABO溶血病存在相关性,孕期检测抗体效价有必要。

Objective： On 152 cases of O blood type of pregnant women blood group antibody titer and hemolytic disease of newborn（HDN） and the relationship.Methods： According to the 0 blood type 16 to 32 weeks of pregnancy in determination of IgG of A（B） value,will be divided into 4 groups（≤1∶ 32,1∶ 64,1∶ 128,≥1∶ 256）,was analyzed the incidence of haemolytic disease of the newborn.On the part of high potency taken by Chinese herbal medicine processing,comparison and analysis of its effect.Results： The incidence of neonatal ABO hemolysis antibody titer was associated with mother,the higher,the higher incidence of haemolytic disease of the newborn,there were significant differences（P 0.05）.Pregnant women with IgG of A（B） high titer take traditional Chinese medicine in the treatment of certain extent reduces the incidence of neonatal hemolytic disease,but the difference was not significant（P 0.05）.Conclusion： O blood type of maternal serum IgG antibody and ABO hemolytic disease of the newborn associated antibody titer,pregnancy testing is necessary.