摘要
目的探讨精液中正常形态精子百分率对体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)受精率、卵裂率、优质胚胎率及临床妊娠率的影响。方法回顾性分析行IVF-ET的543个新鲜取卵周期。根据精子形态分析结果,将正常形态精子百分率(x)不小于参考值下限4%的所有研究对象分为4组,A组:4%≤x≤8%,B组:8%<x≤12%,C组:12%<x≤15%,D组:x>15%。比较4组的受精率、多PN率、卵裂率、优质胚胎率以及临床妊娠率、流产率和异位妊娠率。结果 4组间在女方年龄、男方年龄及不孕年限、获卵数和MⅡ卵数等方面均无显著性差异(P>0.05);在受精率、多PN率、卵裂率和优质胚胎率等受精及胚胎发育方面差异无统计学意义(P>0.05);在临床妊娠率、流产率及异位妊娠率等妊娠结局指标方面差异无统计学意义(P>0.05)。结论正常形态精子≥4%时,逐渐升高的正常形态精子百分率并不会对IVF的受精率、卵裂率、优质胚胎率以及临床妊娠率、流产率等产生显著影响。
Objective： To investigate the influence of normal morphology sperm percentage on clinical outcome of IVF-ET.Methods： We retrospectively analyzed the data of 543 fresh IVF-ET cycles.All subjects with the normal sperm morphology percentage（x） no less than the lower limit of the reference value of 4% were divided into 4 groups： group A： 4%≤x≤8%,group B： 8% x≤ 12%,group C： 12% x≤15% and group D： x 15%.The rates of fertilization,polyspermy,cleavage,high-quality embryo,clinical pregnancy,miscarriage and ectopic pregnancy were compared between the four groups.Results： No significant difference was detected in these parametrics between the four groups（P 0.05）.Conclusion： When above or euqal to 4%,gradually increased normal sperm morphology percentage has no significant effect on IVF outcomes.
出处
《中国优生与遗传杂志》
2013年第7期119-121,123,共4页
Chinese Journal of Birth Health & Heredity
基金
深港创新圈(项目编号:ZYB200907090141A)
