重组人干扰素α-1b联合匹多莫德对儿童反复呼吸道感染免疫状态的影响

Recombinant human interferon α-1b Joint pidotimod impact on the immune status of children with recurrent respiratory infections

【目的】观察重组人干扰素α-1b(IFNa-1b)联合匹多莫德对反复呼吸道感染(RRTI)儿童免疫功能的影响。【方法】选择符合纳入标准的66例反复呼吸道感染患儿,随机分为治疗组和对照组各33例。治疗组给予IFNa-1b肌肉注射,1次/d,连用3～5d;同时口服匹多莫德每次1片(400mg),1次/d,连续用药60d。对照组常规给予病毒唑或喜炎平抗感染对症处理,缓解期加强护理,避免受凉。同时检测两组患儿外周血T淋巴细胞亚群的表达水平及免疫球蛋白的含量。【结果】治疗组治疗后CD3+、CD4+T细胞百分率分别为(57.02±6.05)%,(48.26±1.03)%与CD4+/CD8+比值(1.69±0.15)显著高于对照组(P<0.01),CD8+(27.04±3.91)%明显低于对照组(P<0.01)差异有统计学意义;治疗组免疫球蛋白IgG、IgA与IgM的水平分别为(8.39±3.41)g/L,(8.75±0.28)g/L及(1.64±0.12)g/L,与对照组比较有显著性差异(P<0.01)。【结论】RRTI患儿免疫功能低下,重组人干扰素α-1b联合匹多莫德可明显改善RRTI儿童细胞和体液免疫功能,有效减少患病次数。

[Objective]Effects of recombinant human interferon α -lb （IFNa-lb） the joint pidotimod immune function in children with recurrent respiratory tract infections （RRTI）. [Methods] Choose met the inclusion criteria, 66 patients with recurrent respiratory tract infections in children, Were randomly divided into a treatment group of 33 patients and a control group of 33 patients .The treatment group was given the IFNα-lb intramuscular injection, once a day, once every five days While oral horse Duomo De every time a （400 mg）, once daily , continuous medication for 60 days. Control group ： conventional empirical ribavirin or Xiyanping anti-infective symptomatic treatment to ease the period of enhanced care to avoid the cold. At the same time the content detection of two groups of children with peripheral blood T lymphocyte subsets and the expression level of immunoglobulin. [Results] After treatment, CD3 ＋, CD4＋, the percentage ofT ceils were （57.02 ± 6.05）%, （48.26 ± 1.03）% and the ratio of CD4＋/CD8＋（1.69 ± 0.15） was significantly higher than that in control group （P 〈 0.01）, CD8＋ （27.04 ± 3.91）% was significantly lower than that of the control group （P 〈 0.01） had significant difference; The treatment group of immunoglobulin IgG, IgA and IgM levels were （8.39 ± 3.41） g/L, （8.75 ± 0.28） g/L and （1.64 ± 0.12） g/L, there was significant difference compared with the control group （P 〈 0.01）. [Gonclusion] RRTI low immune function in children, recombinant human interferon alfa- lb United pidotimod can significantly improve （ RRTI ） children＇s cellular and humoral immune function, effectively reduce the number of sick.