甲状旁腺激素与相关疾病的研究进展

Research progress on parathyroid hormone and related diseases

甲状旁腺激素(parathyroid hormone,PTH)是由甲状旁腺主细胞合成、分泌的。由84个氨基酸组成的单链多肽,是调节钙、磷代谢、维持机体钙平衡的主要激素,发挥着升高血钙,降低血磷和酸化血液等生物学效应,对维持细胞外液的内环境恒定起着极为重要的作用。目前PTH在生物学及医学方面的作用越来越受到人们的关注。本文就PTH的基本结构及其与骨质疏松、肾脏疾病、心血管疾病等关系的研究作一综述。

Parathyroid hormone （PTH） is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids, which is the important hormone to regulate the metabolism of calcium and phosphorus and maintain the balance of calcium in body. PTH acts to increase the concentration of calcium and decrease the concentration of phosphorus,aeidificate the blood. In addition, it also plays an important role in maintaining the inner environment of extraeellular fluid.PTH have been received more and more attention in the fields of biology and medicine. This paper reviewed the structure of PTH and the relationships of PHT between osteoporosis, renal disease, cardiovascular disease and so on.