摘要
目的:观察复律宁颗粒对大鼠心律失常的保护作用。方法:将100只SD大鼠随机分为空白组、普罗帕酮组及复律宁颗粒大、中、小剂量组,每组20只。各组连续干预1周,末次干预30 min后从大鼠股静脉分别推注乌头碱或氯化钙,记录Ⅱ导心电图,观察大鼠室性早搏(VPB)、室性心动过速(VT)、心室颤动(VF)及心脏停搏(CA)出现的时间。结果:复律宁颗粒能不同程度延缓乌头碱或氯化钙引发的VPB、VT、VF、CA的发生(P<0.05),并呈一定的剂量依赖性(P<0.05)。结论:复律宁颗粒可多途径防治心律失常。
Objective： To observe the protective effect of ＂Fulvning Granule＂ on arrhythmia in rats.Methods： One hundred SD rats were randomized into blank group,Propafenone group and ＂Fulvning Granule＂ groups（large,medium,small dose）,20 rats in each group.The rats were treated continuously for 1 week.The aconitine and calcium chloride was injected after 30 min treatment of the last time and the ECG was recorded.The times of VPB,VT,VF and CA were recorded.Results： ＂Fulvning Granule＂ can delay the time of VPB,VT,VF and CA induced by aconitine or calcium chloride（P＆lt;0.05）,with a dose-dependent manner（P＆lt;0.05）.Conclusion： ＂Fulvning Granule＂ can prevent and treat arrhythmia by different ways.
出处
《上海中医药大学学报》
CAS
2013年第3期92-94,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市科研计划资助项目(10DZ1974900)
上海市卫生局科研基金资助项目(2011ZJ014)
龙华医院科研基金项目(2012YL54)
关键词
复律宁颗粒
心律失常
乌头碱
氯化钙
＂Fulvning Granule＂
arrhythmia
aconitine
calcium chloride
