基层医院耐甲氧西林金黄色葡萄球菌成人与儿童感染现状与耐药性分析

Analysis of Nosocomial Infection and Antibiotic Resistance of Methicillin-resistant Staphylococcus Aureus in Adult and Children of Primary Hospital

目的调查基层医院临床分离耐甲氧西林金黄色葡萄球菌(MRSA)成人与儿童感染现状及耐药谱,为临床医生合理使用抗生素,提供试验依据。方法对本院2011年1月至2012年10月间临床标本中检出的金黄色葡萄球菌鉴定和药敏试验结果进行回顾性分析。结果 123株金黄色葡萄球菌中检出MRSA67株,MRSA检出率为54.5%。成人与儿童MRSA感染率分别为58.7%与50.0%。MRSA耐药率明显高于甲氧西林敏感金黄色葡萄球菌(MSSA),未检出对万古霉素、替考拉宁及呋喃妥因耐药菌株。结论临床分离的金黄色葡萄球菌对常用抗菌药物呈多药耐药,尤其是MRSA耐药更严重,应根据分离菌株耐药特点选用不同的治疗方案,加强抗菌药物的合理使用,减少MRSA耐药性的发生。

Objective To investigate the clinic distribution and antibiotic resistance of methicillin resistant staphylococcus aureus（MRSA） in adult and children of primary hospital, providing experimental basis that clinical doctors use antibiotic correctly and efficiently. Methods A retrospective analysis was made on Staphylococcus aureus detected in our hospital from Jan 2011 to Oct 2012. Results Among 123 S.aureus isolatess, 67 MRSA isolates were detected, MRSA detection rate was 54.5%, in adult and children was 58.7% and 50.0%. MRSA drug-resistance rate was obviously higher than MSSA from the results of the susceptibility test. No detected isolates were resistant to vancomycin, teicoplanin and nitrofurantoin. Conclusion S.anreus isolated from clinic has multiple resistance to commonly used antimicrobial resistance, especially MRSA strains, different treatment protocols should be chosen according to the drug-resistant characteristics of isolated strains, we will strengthen the rational use of antibiotics to reduce the incidence of MRSA resistance.