miR-144在膀胱癌组织中的表达及临床意义

Expression and Significance of miR-144 in Tissues of Bladder Cancer

目的本文旨在探讨miR-144在膀胱癌组织中的表达及临床意义。方法收集膀胱癌患者手术切除标本58例,癌旁组织为对照,原位杂交技术检测miR-144的表达,分析其与膀胱癌临床参数的关系。结果在58例膀胱癌组织中miR-144阳性表达率为81.0%,癌旁对照组阳性表达率为24.1%,差异有统计学意义,并且miR-144的表达随着膀胱癌临床分期进展而增加,且膀胱癌盆腔淋巴结转移组miR-144的表达显著高于无淋巴结转移组(P<0.01)。结论高表达的miR-144可能参与膀胱癌转移,并可能成为膀胱癌病情进展预测的潜在生物学标志。

Objective To investigate the expression and significance of miR-144 in bladder cancer tissues. Methods 58 tissues and adjacent comparison were collected. Hybridization in situ was performed to detect the miR-144 expression. Results The positive expression rate of the miR-144 was 81.0% in bladder cancer and 24.1% in adjacent normal tissues. The upregulation of miR-144 expression was associated with the progression of clinical stage. And the expression of miR-144 in the group with lymph node metastasis was higher than the group without. Conclusions Overexpression of miR-144 may be associated with metastasis, and it could be regarded as a potential biomarker in bladder cancer progression.