MDR1基因多态性与广西肝癌发生的关系

Correlation between MDR1 polymorphism and primary liver cancer in Guangxi

目的探讨多药耐药基因-1(multidrug resistance gene 1,MDR1)基因C1236Trs 1128503位点多态性与广西肝癌发生的关系。方法采用病例-对照研究方法,从广西肝癌高发区人群中选择109例肝癌患者及109名健康对照者,采用基质辅助激光解吸附电离飞行时间质谱技术(MALDI-TOF-MS)检测MDR1基因C1236Trs 1128503位点的基因型及等位基因频率。结果 MDR1基因C1236Trs1128503位点的CC基因型、CT基因型、TT基因型在病例组与对照组间的分布频率差异均无统计学意义(P>0.05)。等位基因C和T在两组中的分布频率分别为42.20%和57.80%,两组间分布频率的差异无统计学意义(P>0.05)。结论 MDR1基因C1236Trs1128503位点的CT或TT基因型携带者的肝癌发病风险未见显著增加,MDR1基因多态性可能不是广西肝癌发生的遗传易感因素。

Objective To evaluate the correlation between the C1236T rs 1128503 polymorphism in the muhidrug resistance 1 （MDR1） gene and primary liver cancer （PLC） in a Guangxi Zhuang population. Methods A case-control study of 109 PLC patients and 109 healthy controls was conducted in a Guangxi area with a high PLC incidence.Genotypes and alleles of MDR1 C1236T rs 1128503 were detected by matrix-assisted laser desorption ionization time-of-flight mass spectrometry（ MALDI-TOF-MS ）. Results The PLC and control group did not differ significantly in frequencies of MDR1 rs 1128503 CC,CT,or TT genotypes,or in frequencies of C and T alleles（P〉0.05）.The frequencies of C and T alleles were 42.20% and 57.80%. Conclusions Risk of PLC is not increased in carriers of the MDR1 C1236T rs 1128503 CT or TT genotypes.MDR1 polymorphism may not be a genetic susceptibility factor for PLC.