80例原发性腹膜后肿瘤切除术预后因素的分析

Prognostic analysis of patients with primary retroperitoneal tumors undergoing surgical resection

目的探讨原发性腹膜后肿瘤(primary retroperitoneal tumor,PRT)患者手术切除预后的影响因素。方法回顾性分析2001年6月至2012年6月住院治疗的80例原发性腹膜后肿瘤患者的临床病理资料,采用Kaplan-Meier方法、Cox比例风险回归模型和Log-rank检验,分析影响PRT患者预后的相关因素。结果本组病例均获随访,中位随访时间为40.4个月,1年、3年、5年累计生存率分别为92.5%、73.1%、67.5%,中位生存时间为67个月。单因素分析显示,手术方式、肿瘤大小、肿瘤性质、有丝分裂数、周围器官侵犯等因素影响PRT患者术后累计生存率(P<0.05)。多因素分析显示,手术方式、肿瘤性质、有丝分裂数、周围器官侵犯等是影响PRT预后的独立影响因素(P<0.05)。结论手术切除是PRT患者有效的治疗手段,肿瘤性质、手术方式、周围器官侵犯、有丝分裂数是影响PRT预后的独立影响因素。

Objective To explore the prognostic factors of patients with primary retroperitoneal tumor （PRT） treated by surgical resection. Methods We retrospectively analyzed 80 patients with PRT treated in the First Affiliated Hospital of Guangxi Medical Uni- versity between June 2001 and June 2012.Survival and prognosis were analyzed using the Kaplan-Meier method,the Cox proportional hazard model and the log-rank test. Results All patients were followed up for a median of 40.4 months, and the 1-, 3-, and 5-year cumulative survival rates were 92.5% ,73.1% and 67.5%.Median survival time was 67 months. Univariate analysis identified the fol- lowing significant predictors of survival （P〈O.05）： surgical method, tumor size, tumor characteristics, mitotic counts of tumor cells, and invasion of adjacent organs.Multivariate analysis identified the following independent prognostic factors（P〈0.05）：surgical method, tumor characteristics,mitotic counts of the tumor cells and invasion of adjacent organs. Conclusion Surgical resection is the most ef- fective treatment for PRT.Tumor characteristics, surgical method,invasion of adjacent organs and mitotic counts of tumor cells are the most important prognostic factors for PRT.